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PATHFAST™ - B·R·A·H·M·S PCT Brochure

PATHFAST™ - B·R·A·H·M·S PCT Brochure

PATHFAST™ - B·R·A·H·M·S PCT Brochure

Product catalog summary
Introduction
The document discusses the B.R.A.H.M.S PCT assay, a diagnostic tool for sepsis, which is a leading cause of death in intensive care units. The assay is recognized for its high sensitivity and rapid results, aiding in antibiotic stewardship and sepsis management.

Specifications
The B.R.A.H.M.S PCT assay can process up to six samples in parallel in less than 17 minutes using whole blood, plasma, or serum. It provides high-sensitive central lab quality results.

Sepsis Overview
Sepsis affects 27-30 million people annually, with 6-9 million deaths. Early recognition and diagnosis are crucial for improving outcomes. PCT is a biomarker used for diagnosing sepsis and assessing its severity.

Procalcitonin (PCT) Details
PCT is a precursor of calcitonin, expressed in response to systemic bacterial infection. It aids in diagnosing sepsis and guiding antibiotic therapy. PCT levels in sepsis are typically higher than 1-2 ng/ml, reaching up to 100 ng/ml or more.

Antibiotic Stewardship
Overuse of antibiotics, especially in lower respiratory tract infections, contributes to antimicrobial resistance. The B.R.A.H.M.S PCT assay helps determine the optimal duration of antibiotic therapy, reducing unnecessary use.

Assay Standardization and Performance
The assay is standardized against the B.R.A.H.M.S PCT sensitive KRYPTOR assay. It has a measuring range of 0.02 - 100 ng/ml and demonstrates high correlation with other assays. Sample stability varies with temperature, and precision is maintained across different concentrations.

Test Principle
The PATHFASTTM B.R.A.H.M.S PCT assay uses non-competitive CLEIA combined with MAGTRATION® technology. It involves forming an immune complex with enzyme-labeled antibodies, and luminescence intensity is measured to determine PCT concentration.

Application and Benefits
The PATHFASTTM system offers rapid, high-quality results suitable for point-of-care testing. It is flexible, allowing use in emergency departments or intensive care units, and supports clinical decision-making.

Conclusion
The B.R.A.H.M.S PCT assay on the PATHFASTTM system accelerates clinical decision-making, is well-validated, and supports sepsis diagnostics with high reliability. It is a valuable tool for reducing treatment costs and improving patient outcomes.
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Catalog excerpts

PATHFAST™ - B·R·A·H·M·S PCT Brochure-1

Master the challenge in sepsis diagnostic • up to 6 samples in parallel • in less than 17 minutes • out of whole blood, plasma or serum • in high-sensitive central lab quality • for guided antibiotic stewardship cs List on WHO Essential In-vitro Di

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PATHFAST™ - B·R·A·H·M·S PCT Brochure-2

PCT in sepsis patients Sepsis with acute organ dysfunction (severe sepsis) is the number one cause of death in the non-coronary intensive care unit and one of the most significant challenges in critical care [1]: Fig. 1: PCT increase reflects the likelihood to develop from a healthy condition to the most severe states of disease (severe sepsis and septic shock) 6 - 9 million people die per year – 1 death every 3-4 seconds Survivors may face lifelong consequences Local infections Systemic infections Severe sepsis PCT plasma concentration (ng/ml) 27 - 30 million people are affected by sepsis every...

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PATHFAST™ - B·R·A·H·M·S PCT Brochure-3

Specific performance data The test principle of PATHFAST TM B.R.A.H.M.S PCT is based on non-competitive CLEIA combined with MAGTRATION® technology and is standardised against the B.R.A.H.M.S PCT sensitive KRYPTOR assay. During incubation of the sample with alkaline phosphatase labelled anti-PCT monoclonal antibody and antiPCT monoclonal antibody coated magnetic particles, the PCT of the sample binds to the anti-PCT antibodies forming an immune complex with enzyme labelled antibody and antibody coated magnetic particles. After removing the unbound substances by MAGTRATION® technology, a chemiluminescent...

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PATHFAST™ - B·R·A·H·M·S PCT Brochure-4

Application and benefit of PATHFAST TM B.R.A.H.M.S PCT With its easy and intuitive design, PATHFAST TM offers an easy way to analyse your patient samples by performing only 3 simple steps. Collect whole blood, serum or plasma samples, using heparin-NA, heparin-Li or EDTA collection tubes. Transfer 100 µL sample into each sample well of the reagent cartridges. Due to its reagent design and reagent throughput, PATHFAST TM is designed as an optimal companion combining the quality of results of a central lab analyser with the flexibility of a point of care testing device in one instrument. The PATHFAST...

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PATHFAST™ - B·R·A·H·M·S PCT Brochure-5

The Advantage of using a quality B.R.A.H.M.S PCT In order to optimize the process of ED patient flow, a fast decision on a broad spectrum of diseases and injuries helps contribute to a shorter average length of stay in the ED. A reliable, stable and clinically proven diagnostic solution supports the clinical-based decision, lowering patient risk and reducing treatment costs. The application of the B.R.A.H.M.S PCT on the PATHFAST TM system will comply with the highest testing standard possible, and will support the sepsis diagnostic for the future. The clinical reliability of B.R.A.H.M.S PCT has...

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PATHFAST™ - B·R·A·H·M·S PCT Brochure-6

Product List PATHFAST TM for critical care and sepsis diagnostics Item number Pack size PATHFAST TM pipette tips PATHFAST TM B.R. A.H.M.S PCT control set PATHFAST TM Presepsin control set SYSTEM PATHFAST TM Immunoanalyser Analyzer for the detection of cardiac and other emergency parameters and sepsis CONSUMABLES AND ACCESSORIES REAGENT KITS FOR CRITICAL CARE DIAGNOSTICS REAGENT KITS FOR SEPSIS DIAGNOSTICS PHC Europe B.V. Nijverheidsweg 120, 4879 AZ Etten-Leur, The Netherlands Phone: + 31 76 543 38 33 email: [email protected]

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.