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CaloBox

Product catalog summary

Introduction
The CaloBox is an innovative system designed for indirect calorimetry in mice and other small animals. It is user-friendly and compact, allowing for both standard and advanced measurements by simply connecting it to an animal cuvette and pressing 'Start'. It is commonly used in research and teaching for studying animal metabolism, nutrition, heat regulation, bioenergetics, and more.

Key Features
The CaloBox offers automated measurement of metabolic rate, energy expenditure (EE), and respiratory exchange ratio (RER) with push-button operation. It features a compact design, flexible applications, and a built-in battery option. All raw sensor data is stored for further analysis.

General Functions
The system includes internal pumps for airflow through the animal cuvette, with a reliable measurement interval as short as 4 seconds. It measures O2, CO2, and water vapor content in sample air and compares it to reference air. It calculates metabolic rates, including O2 consumption, CO2 production, and water vapor evaporation, and determines energy expenditure based on these metrics. The system automatically adjusts gas sensors with reference air at preset intervals and continuously records and displays results.

Technical Specifications
The CaloBox measures 35 x 30 x 16 cm and weighs 3.5 kg. It includes a mass flowmeter for sample air with a response time of 60 milliseconds and repeatability of +/- 0.5%. The electrochemical O2-cell has a range of 0-25 Vol% with a response time of 12 seconds and accuracy of +/- 2%. CO2 measurement is conducted using an NDIR-cell with a range of 0-5000 ppm and accuracy of +/- 30 ppm. Additional sensors include an HT-Sensor for relative humidity and a thermocouple for temperature.

Data Interpretation
Typical data from a djungarian hamster shows O2 consumption, CO2 production, and water vapor output over time, indicating system warmup, total water vapor from the cage, and metabolic water output, as well as ultradian activity peaks when the animal is placed in the cage.

Catalog excerpts

Indirect Calorimetry CaloBox INTRODUCTION The CaloBox is a new system for indirect calorimetry in mice and other small animals. Its ease-of-use and compact design facilitates standard measurements as well as advanced applications − simply connect the CaloBox to an animal cuvette and press „Start“. Common applications in research and teaching are: animal metabolism, nutrition, heat regulation, thermoregulation, bioenergetics, animal behavior, energy balance, resting metabolic rate, energetics of locomotion, and many more. Automated measurement of metabolic rate, energy expenditure (EE), and respiratory exchange ratio (RER) Push button operation No tedious drying of the airflow required Compact design Flexible applications Built-in battery option All raw sensor data is stored CaloBox Measurement Unit CaloBox Schematic Setup Internal pumps for air flow through animal cuvette 30..150 L/h Down to 4 sec reliable measurement interval No drying of sample or reference air required Measurement of O2 , CO2, and water vapor content in sample air; Comparison to reference air Calculation of metabolic rates: ̇  O2 consumption per unit time (VO2 ) ̇ CO2 )  Carbon dioxide production (V ̇  Water vapor evaporation (VH2O)  Respiratory exchange ratio (RER, RQ) ̇ Calculates energy expenditure (EE) based on VO2 and RER Automatic adjustment of gas sensors with reference air in preset intervals (zero adjustment) Continuous record and result display Raw data of all sensors stored for user defined calculations

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Indirect Calorimetry CaloBox CaloBox – Operational setup with mouse cuvette CO2 production (mL/min) O2 consumption (mL/min) system warmup animal placed in cage ultradian activity peaks water vapor (mL/min) total water vapor from cage and metabolic water output CaloBox software interface Typical data (djungarian hamster) Dimensions: 35 x 30 x 16 cm; weight 3.5 kg Mass flowmeter for sample air: 0..5 sLpm (0..150 L/h), response time 60 msec, repeatability +/- 0.5% Electrochemical O2-cell: Range 0..25 Vol%, response time 12 sec, accuracy +/- 2% CO2 measurement: NDIR-cell (non dispersive infrared),...

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