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PROSPECT 3-Year Imaging Data

PROSPECT 3-Year Imaging Data
2Pages

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PROSPECT 3-Year Imaging Data PROSPECT - Providing Regional Observations to Study Predictors of Events in the Coronary Tree As presented by Gregg Stone, MD on behalf of the PROSPECT investigators Study Design: 700 patient, multi-center, natural history study in patients with acute coronary syndromes Primary Endpoint: MACE attributable to Ml, unstable or stable angina requiring hospitalization or revascularization Inclusion / Exclusion criteria: ACS, only uncomplicated, successful PCI of one or two vessels The three statistically significant predictors of non-culprit lesion risk by multivariate analysis were plaque burden > 70%, presence of a VH-TCFA, and MLA < 4.0 mm2 PROSPECT: Methodology Virtual histology lesion classification Lesions are classified into S main types Pathological intimal thickening (PIT) ^ J,. 4, Thick cap fibroatheroma (ThCFA) O, 6. VH thin cap fibroatheroma (VH-TCFA} (pp turned hiyli ri^k] 3-. Pathological intimal thickening (PIT) Non Culprit Lesion Related Events ^^^k^ Legion level events (M r^erVts rroT 2BS3 lr=io-T in euy FT at n;Jnn J.fl JTT> Virtual HiFitoIy Plaque Type VH® IVUS lesion types used in PROSPECT Hazard Ratios by VH® IVUS lesion type as defined in PROSPECT The angiogram cannot predict which lesions will progress to events within three years (all lesions were considered non-significant by the investigator at index). A lesion identified as a VH-TCFA is a statistically significant predictor of MACE at three years. The risk of MACE increases when combined with plaque burden and MLA parameters. Volcano and the Volcano Logo are registered trademarks of Volcano Corporation. Slides courtesy of Gregg Stone, MD as presented at TCT 2009.

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PROSPECT 3-Year Imaging Data Event Rate Categories: Culprit Lesion Related • Stent thrombosis, restenosis, new side branch lesion Non-Culprit Lesion Related • Rapid lesion progression (lesion progression >20% by QCA at event from baseline) • Non-rapid lesion progression (lesion progression <20% at event from baseline) Positive and Negative Predictors of Event Risk per PROSPECT Definitions Using VH® IVUS: Culprit Lesion Related Events TCFA TCF^ * MLA TCF* * FB *70Ti TCFA - FB »7T/S * pvjiua o.oMi ^DJOCOI 4.0001 --o.cooi Non-Culprit lesion risk stratification using significant predictors of...

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PROSPECT 3-Year Imaging Data 2Pages

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PROSPECT 3-Year Imaging Data
2Pages