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Simeox Indication The SIMEOX therapy provides effective and comfortable airway clearance for patients suffering from chronic lung diseases (such as Cystic Fibrosis, Bronchiectasis, COPD) having lung congestion and difficulties to mobilize their mucus. Technology SIMEOX features a unique technology having a direct action on The SIMEOX technology allows a more distal drainage of the mucus without increasing the fatigue of the patient, as SIMEOX generates non-invasively during patient the device is used in total relaxation. exhalation through a mouthpiece, a succession of very short air depressions disseminating throughout the Compared to oscillating PEP devices, SIMEOX delivers a bronchial tree a pneumatic vibratory signal. The effect is a more consistent and specific signal that impacts the transient modification of the rheology of the mucus, rheology of the bronchial mucus. reducing its viscosity and improving its mobilization toward higher bronchial tree. Mobilized mucus is then Unlike other airway clearance instrumental aids such as expectorated through natural cough. IPPV or Mechanical In-Exsufflation, the SIMEOX device does not deliver any continuous flow, in order to reduce SIMEOX development is based on 5 years of fundamental research in partnership with prestigious research centers and university hospitals about the behavior and physical properties of the bronchial mucus.

> Liquefy and transport bronchial mucus, even from the very distal parts of the lungs > No increase of the patient fatigue > Reduced risk of bronchial collapsus > No side effect, very few contraindications > Safe and easy to handle / Easy to learn > Hygienic concept with exhalation-kit replacement > Has ergonomics for being used by the patient himself (autonomy in airway clearance management) or in addition to the physiotherapist's intervention Clinical outcomes > Improvement of lung function characteristics such as FEV1 and FVC 1 2 > Improvement of the quality of life in COPD...