Multidisciplinary Application of Serum Tumor Markers

Product catalog summary

Overview: The document discusses the application of serum tumor markers in optimizing cancer prognosis and monitoring recurrence. It highlights the clinical significance of various tumor markers, their targeted cancers, roles, and limitations.

Key Tumor Markers and Their Applications:

Prostate Cancer: tPSA and fPSA are used for screening, with the fPSA/tPSA ratio improving specificity and reducing unnecessary biopsies.
Colorectal, Gastric, Pancreatic, Lung, and Breast Cancers: CEA is used for monitoring recurrence and treatment response, though it has low specificity.
Hepatocellular Carcinoma (HCC): AFP is the gold standard for diagnosis, but has low sensitivity in early stages.
Non-Small Cell Lung Cancer (NSCLC): CYFRA21-1 is preferred for squamous cell carcinoma, offering higher sensitivity and specificity.
Pancreatic, Biliary Tract, and Gastric Cancers: CA19-9 is the best marker for pancreatic cancer, though it has limitations in certain populations.
Ovarian Cancer: CA125 is the primary marker, often combined with HE4 for improved specificity.

Consensus Recommendations:

Prostate Cancer: Combining tPSA and fPSA reduces false positives.
Ovarian Cancer: CA125 and HE4 achieve high accuracy.
Pancreatic Cancer: Combining CA19-9, CEA, and CA125 increases sensitivity.

Advantages of Combined Detection: Combining tumor markers enhances sensitivity and specificity, compensating for individual limitations. Specific combinations are recommended for various cancers to improve diagnostic accuracy and clinical utility.

Technical Specifications of Detection System:

Rapid detection with a throughput of 80 tests/hour.
Portable and semi-automatic system with touch screen operation.
Supports real-time information sharing and is economical and efficient.

Catalog excerpts

Multidisciplinary Application of Serum Tumor Markers-1

Urology Gastrointestinal Gynecology Surgery Oncology Respiratory Hepatobiliary Gastroenterology Department Department Surgery

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Multidisciplinary Application of Serum Tumor Markers-2

Clinical Significance Tumor markers are often proteins, and their testings play a critical role in cancer management by tracking disease progression and assessing treatment response over time. Results serve as valuable prognostic indicators and are fundamentally used for detecting disease recurrence post-treatment, prompting further investigation. tPSA (Total Prostate-Specific Antigen) fPSA (Free Prostate-Specific Antigen) Targeted Cancer: Prostate cancer (PCa) Role: tPSA is the cornerstone for PCa screening. Elevated tPSA (> 4 ng/mL) triggers further investigation, but its low specificity (elevated...

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Multidisciplinary Application of Serum Tumor Markers-3

Except for the high specificity of PSA in diagnosing Prostate cancer, individual testing of other tumor markers lacks high specificity for specific cancer types. Combining markers increases sensitivity and specificity by compensating for individual limitations: Ovarian cancer: CA125 + HE4 achieves 93.8% accuracy. Pancreatic cancer: CA19-9 + CEA + CA125 raises sensitivity to 82%. Prostate cancer: tPSA + fPSA ratio reduces false positives by 30% in the gray zone. Recommended Combined Markers Sensitivity (%) Specificity (%) Clinical Utility Prostate Cancer tPSA + fPSA (F/T ratio) 44-67 Reduces unnecessary...

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Multidisciplinary Application of Serum Tumor Markers-4

^Poclight Nanjing Poclight Biotechnology Co., Ltd. Address: South Side, 2nd Floor, Building A02, Biopharmaceutical Valley Accelerator (Phase III), No. 142 Huakang Road, Jiangbei New District, Nanjing City, Jiangsu Province, 210000, P R. China E-mail: [email protected] Website: www.poclight.com

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