Urology Gastrointestinal Gynecology Surgery Oncology Respiratory Hepatobiliary Gastroenterology Department Department Surgery

Clinical Significance Tumor markers are often proteins, and their testings play a critical role in cancer management by tracking disease progression and assessing treatment response over time. Results serve as valuable prognostic indicators and are fundamentally used for detecting disease recurrence post-treatment, prompting further investigation. tPSA (Total Prostate-Specific Antigen) fPSA (Free Prostate-Specific Antigen) Targeted Cancer: Prostate cancer (PCa) Role: tPSA is the cornerstone for PCa screening. Elevated tPSA (> 4 ng/mL) triggers further investigation, but its low specificity (elevated...

Except for the high specificity of PSA in diagnosing Prostate cancer, individual testing of other tumor markers lacks high specificity for specific cancer types. Combining markers increases sensitivity and specificity by compensating for individual limitations: Ovarian cancer: CA125 + HE4 achieves 93.8% accuracy. Pancreatic cancer: CA19-9 + CEA + CA125 raises sensitivity to 82%. Prostate cancer: tPSA + fPSA ratio reduces false positives by 30% in the gray zone. Recommended Combined Markers Sensitivity (%) Specificity (%) Clinical Utility Prostate Cancer tPSA + fPSA (F/T ratio) 44-67 Reduces unnecessary...

^Poclight Nanjing Poclight Biotechnology Co., Ltd. Address: South Side, 2nd Floor, Building A02, Biopharmaceutical Valley Accelerator (Phase III), No. 142 Huakang Road, Jiangbei New District, Nanjing City, Jiangsu Province, 210000, P R. China E-mail: [email protected] Website: www.poclight.com