Next-Generation Bioprinting

MAKE TISSUES REAL Poietis at a glance Founded in 2014 as a spin-off from INSERM and the University of Bordeaux, Poietis’ mission is to provide solutions leveraging its proprietary next-generation bioprinting (NGB) platform and bring tissue engineering therapies to patients. Poietis gathers a strong and interdisciplinary team of biologists, physicists, AI specialists, developers and pharmacists with extremely rich and diverse expertise. Together, we thrive to develop what is the most advanced bioprinting platform to date and use it to create tissues for key applications such as regenerative medicine...

A NEW, DISRUPTIVE 4D BIOPRINTING APPROACH TO MAKE COMPLEX, FUNCTIONAL LIVING TISSUES Single-cell resolution While tissues and organs are organized at a micron scale, conventional tissue engineering and 3D bioprinting techniques are limited to coarse resolution of 300-500µm. NGB-R™ solves such critical limitations by introducing unique single-cell resolution technologies, allowing to precisely control cellular interactions and guide biological processes of organogenesis (more on page 6). Boasting single-cell resolution capabilities and based on state-ofthe-art robotics, automation, control and...

NGB-R™ INSTRUMENT, FULLY-INTEGRATED BIOPRINTING PLATFORM Smart software suite State-of-the-art hardware Before being an actual instrument, NGB-R™ first consists of a well-devised software suite designed to allow for seamless workflow and user-friendly operation, both on your computer as well as directly on the unit itself. The NGB-R™ instrument itself was conceived as an all-in-one, stand-alone bioprinting platform, fully-integrated into a tailored, stainless-steel made biosafety cabinet (BSC). Design your tissues with a large collection of pre-defined yet editable tools, anywhere you are. Customize,...

ALL-IN-ONE BIOFABRICATION CABINET FOR BIOPRINTING & CELL-CULTURE WORK Fully integrated biosafety cabinet Save space & money with an all-in-one cabinet for all your cell & bioprinting work High-end 6-axis robotic arm Enjoy unrivaled precision & automation with fully-motorized robotics Large 21” touch-screen interface Operate your bioprinter in optimal conditions with stunning visualization Bio-extrusion & micro-valve heads Continue your current bioprinting work & transfer your protocols to NGB-R™ Exclusive laser bioprinting head Discover single-cell resolution and keep total control over cell...

HIGH-RESOLUTION LASER-ASSISTED BIOPRINTING, POIETIS’ WORLDWIDE EXCLUSIVE PATENTS A decade of research As a result of 10+ years’ thorough research at INSERM and the University of Bordeaux, we eventually developed the first and only laser-assisted bioprinting (LAB) platform dedicated to research in tissue engineering and biology. Game-changing technology Ideal for countless regenerative medicine applications, our laser-assisted bioprinting technology makes it possible to print living cells and biomaterials with a cell-level resolution, giving tissue engineers total control over cells density, distribution...

WHY ADD LASER BIOPRINTING TO YOUR CURRENT EXTRUSION WORK? All resolution and precision levels available Ideal for cell-loaded bioinks NGB-R™ is the first commercially-available instrument to boast laser-assisted bioprinting, allowing to deposit micro droplets (with size from 300 to 50µm) of cell bioink with a precision of a few microns only. LAB also offers unrivaled precision compared to other printing techniques and thus provides total control over cell distribution and thus cell patterns within bioprinted tissues. With outstanding printing capabilities, all levels of resolution are possible,...

COMPLEMENTARY PRINTING HEADS, FOR AN ALL-IN-ONE BIOPRINTING PLATFORM Up to 3 nozzle-based printing heads Complementary techniques, not opposed NGB-R™ comes with a bio-extrusion and a micro-valve printing head by default, and a 3 rd additional printing head as an option. We certainly promote laser-assisted bioprinting as a fantastic and better way to bioprint living cells. However, bio-extrusion and micro-valve techniques are far from irrelevant. As a matter of a fact, NGB-R™ is equipped with these printing heads too. These may be used for simultaneous dispensing of cells and biomaterial or an...

PRINTING HEAD ACCESSORIES BIOINK & CELL COMPATIBILITY Fully customizable printing heads Versatile, multi-modal solutions Configure NGB-R™’s complementary printing slots as you please with up to 3 additional printing heads and plenty of options tailored to your applications. NGB-R™ 4D bioprinting platform was designed as an extremely versatile instrument capable to work with any kind of polymerbased biomaterials. With laser (LAB), bio-extrusion and microvalve complementary printing heads, NGB-R™ offers a suitable option for any bioink/biomaterial such as: Bio-extrusion and/or micro-valve, Peltier...

WHAT YOU DESIGN... CAD > HMI Save your designs and edit them at any time. When complete, transfer your .bio files over to the NGB-R™ platform in no time. Don’t worry, all your parameters may still be edited afterwards. Create or import your tissue designs layer by layer, every step of the way. For any cell type, select a printing method, design specific patterns and adjust cell distribution just as you need it. *CAD = Computer Assisted Design The instrument’s user interface allows for innumerable options among which is the possibility to organize, sequence and even add printing jobs in a desired...

Initiating printing is as simple as a 1-touch process. The rest is a hands-off, automated operation. The NGB-R™ platform follows the exact sequence defined and displays progress on screen. Along with striking visualization tools, PIA™ may also perform image analysis such as measuring patterns diameters, counting cells in every well and much more. All this, fully automatically of course. VISUALIZE PIA™* Use the NGB-R™’s cutting-edge imaging devices profitably to monitor printing outcome. PIA™ software allows to recapitulate every single layer as well as view all cells in a stunning 3D mode. *PIA™...