Hybrid Energy Technology Surgen Hybrid Energy - A novel Micro-Needles Technology for Skin Treatment 1 Alex Levenberg, M.D. , Cruzira T Salazar, M.D. , Marie Christine Branchet, PhD , Sylvie Boisnic, M.D. 1 Physicians Center, Plastic Surgery Dept., Tel Aviv, Israel 2 Pollogen Ltd. Clinical Dept., Tel Aviv, Israel 3 GREDECO Research Association, Paris, France.

Hybrid Energy Technology Abstract Introduction: Demand for skin rejuvenation and anti-aging procedures with minimal down time and low risk has led to the development of methods for non-surgical treatment of wrinkles, scars and general facial enhancement. In the past few years, fractional radiofrequency (RF) systems have been introduced that enable controlled skin resurfacing. The new Hybrid Energy™ (HE) micro needles technology delivers hot and electrical energies creating micro ablation thus promoting natural fractional healing process for dermal refilling and skin renewal. The objective of...

Hybrid Energy Technology Methods Pollogen’s Surgen System Hybrid Energy Platform The Surgen system (Figure 1) is a new platform composed of a main unit and two applicators: The novel Hybrid Energy (HE) micro needles applicator and the TriFractional applicator (same as the previously introduced A3F applicator for the Pollogen Maximus device). Hybrid Energy technology combines Dual energy: Thermal RF energy for safe, effective and virtually painless penetration of the skin and electrical energy directly applied to the specific target area, enhancing the total clinical effect. Hybrid Energy combined...

Hybrid Energy Technology Ex-vivo Histology Evaluation Skin fragments harvested from donors undergoing plastic surgery were maintained in survival condition using the Gredeco ex vivo skin model and artificially aged by Ultraviolet (UV) irradiation, as previously described by Boisnic and Branchet(6, 17). One treatment was performed with the HE applicator using Low and High power programs. Histological modifications of the skin were analyzed, using H&E staining, at different intervals between Day 0 and Day 10 after the treatment, Additional biochemical analyses were done to identify changes in dermal...

Hybrid Energy™ EXPECT MORE Before Immediatelly after 9 days after Treatment 18 days after Treatment Figure 4: Immediate and short term effect. A slight erythema is visible immediately after the treatment. Fine lines appearance continues to improve during the following weeks. Before 20 days after 3 Treatments Figure 5: Long term results after 3 treatments. Improvement of forehead wrinkles is clearly noticed. Before 41 days after 3 Treatments Before 41 days after 3 Treatments Figure 6: Long term results after 3 treatments. Volumizing effect of left and right naso labial area.

Hybrid Energy Technology 23 days after 3 Treatments Figure 7: 3D Primos imaging and analysis of long term results of periorbital wrinkle reduction 23 days following 3 HE treatments. The analysis was performed on 2 zones of the 3D mapping (Zones A and B, marked on the images above) Zone A – Measured reduction of wrinkle volume from 0.434mm3 to 0.139 mm3 (68% improvemnt), this can also be noticed by a reduction of green color in this area translating to reduction in wrinkle depth. Zone B- The Graph displayed above demonstrates reduction of 198 microns in wrinkle depth, as measured by the Primos...

Hybrid Energy Technology Ex-vivo Histology Initial histology photos demonstrated the microneedles treatment impact in the dermal and epidermal layers and the healing process. Results indicated correlations between treatment parameters (Low or extra High) and the size of the dermal and epidermal effect, extent of effect and duration of the healing. In both parameters, the effect in term of intensity and healing was as expected. Sample photos are demonstrated in Figure 8. Figure 8: Ex-vivo UV aged skin histology samples at D0 (Left) and D2 in survival medium (Right). (H&E stain, magnification:...

Hybrid Energy Technology Patient satisfaction was high (dissatisfied, 0%; neutral, 7%; satisfied, 60%; and very satisfied, 33%). All participants in the micro needles treatment group experienced transient erythema, mild edema, and mild to moderate purpura that resolved in 5 to 10 days, and they returned to normal activities within 24 hours. There were no adverse events or complications in the micro needles group. All patients in the surgical face-lift group experienced scarring at surgical margins, erythema, edema, and ecchymosis, and they returned to normal activities on suture removal at 7...