Introduction: The PreciGenome microfluidic pressure/flow control system (PG-MFC series) provides pulse-free precise positive and negative pressure. Stable constant flow rates can be set and controlled when used in conjunction with external liquid flow sensors. The microfluidic pressure controller operates in a wide range with fast response time and high accuracy. Our pressure controller software provides a user-friendly interface with an integrated touch screen. No external computer is needed even for complicated process configuration. System Benefits: • Compact and portable design • Precise and accurate pressure/flow outputs • Controllable liquid flow rate output with external liquid flow sensors • Controlled sample volume injection with external liquid flow sensors • Easy connection with Luer lock standard connectors • No external pressure source required (can be connected to an external pressure source for higher pressure) • No external computer required • Compatible with PreciGenome pinch/isolation valves, rotary valves, high-speed imaging system • Air flow rate monitoring; air leakage detection • CAN, USB and digital IO ports available • OEM service and module integration available System Contents: • Microfluidic Luer Lock Fittings Kit for Pressure Controller Connection, 2 sets • Liquid flow rate sensor (optional) • Microfluidic reservoir kit, 1.5/2ml,15ml, 50ml, 100/200ml (optional) • Microfluidic reservoir connectors, up to 230ul, 30/pack (optional) Applications: • Liquid handing • Automatic reagent distribution, sequential injection of reagents with controlled volume • Instrumentation for point of care testing, • Analytical Instrumentation • Droplets generation & applications (dPCR, single cell encapsulation, NGS target sample enrichment, etc.) • Organic /polymer syntheses, nanoparticle syntheses, such as PLGA, liposome synthesis • Drug transportation studies • Cell culture and cell perfusion • Other microfluidics applications to manipulate fluids Address: 2176 Ringwood Ave. San Jose, CA, USA, 95131 Email:

Microfluidic Solutions Provider • PreciGenome System Specifications: • Pressure sensor accuracy of ±0.25 %FSS BFSL (Full-Scale Span Best Fit Straight Line), sensor resolution: 0.0061 % • Flow rate repeatability: below 1% of the measured value • Highest liquid flow sensitivity down to <1 ^l/min • Maximum flow rate for water-based liquids: 10 ml/min; • Maximum flow rate for hydrocarbons: 80 ml/min Table of detailed specifications for different models: Address: 2176 Ringwood Ave. San Jose, CA, USA, 95131 V1.2 Email: [email protected] PAGE 2 / 3

Microfluidic Solutions Provider Dimensions: Unit: mm Electrical Connections: Luer connector for external pressure source Digital I/O ( IN1 & IN3 ≤ 3.3V ) Trigger input3.3 - 24V ( IN2 & IN4 ) USB to serial port Trigger output (No load capacity) Controllable 24V output DC 24V output CAN Power connector RJ45 Power switch Warning: Hot plugging is not supported Address: 2176 Ringwood Ave. San Jose, CA, USA, 95131 Email: [email protected]