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Sensors for Biotech & Pharma Industries Micro-invasive or even contactless measurements For microbial & cell culture From μL to m3 scale Bioprocess development & drug screening Quality control

Sensors for the Biotech & Pharma Industries Biomass Contact us and we find your customized solution!

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Sensors for the Biotech & Pharma Industries We bring to light what‘s inside... Products Made in Germany Company Profile PreSens offers a broad range of sensor systems for end users in Bioprocess Control, Biological & Environmental Research, the Food & Beverage industry as well as other industrial applications. Based on research activities started in the 1980‘s PreSens Precision Sensing GmbH was founded in 1997 as a spin-off from the University of Regensburg, Germany. We offer systems for Oxygen measurement in gases and liquids Non-invasive online pH, CO2 and oxygen measurement Oxygen and pH...

...and work for the following industries. Biotech & Pharma Research Our Biotech & Pharma business field helps pharmaceutical companies such as Roche and DSM to improve their bioprocess develQuality Control opment with PreSens sensors. With two decades of customer feedback our product development provides efficient solutions for your needs. Food & Beverage A cooperation with the market leader for beverage filling systems, Krones AG, Neutraubling, triggered our Food & Beverage business field in the late 1990‘s. PreSens supplies sensors for checking the oxygen-tightness of packaging and...

Sensors for the Biotech & Pharma Industries sensors Sensor Solutions Online Monitoring of O2, pH, CO2 and biomass PreSens sensors for Biotech & Pharma help companies like Roche and DSM to improve their bioprocesses. With our non-invasive measurement systems no more time consuming sampling is necessary and they allow simultaneous monitoring of multiple samples. While our various O2 sensors suit almost any application, pH sensors are optimized for measurements in cultivations, and our CO2 sensors work in selected applications depending on the sterilization method and the process conditions....

Bioprocess Development: Sensors in Small-scale Systems The online measurement of dissolved oxygen concentration and pH in shaken bioreactors paves the way for proper scale up or scale down activities - from bench-top stirred bioreactors to larger or smaller scales. So far, appropriate measurement methods for culture monitoring in shake flasks were missing. With the application of single-use optical sensors culture conditions can be monitored online without sampling. They enable highly parallelized measurements in multiwell plates and flasks. Limitations can be detected in time while the...

Sensors for the Biotech & Pharma Industries Sensor Solutions for Biotech & Pharma Contact us and we find your customized solution!

PreSens offers customized sensor technology solutions. Right from the beginning PreSens can be your partner while finding new approaches: from specifics tions to implementation up to production of your tool. Don’t hesitate to ask for your individual solution: engineering@presens.de SENSOR SOLUTIONS Sensor Spots for contactless measurement in transparent culture vessels Disposable Shake Flasks (SFS), Multidishes (Oxo- and HydroDishes), Spinner Flasks (SPS), Cell Culture Flasks (CFS), Cell Culture Tubes (iTubes) with integrated sensors Oxygen Probes OIM for bioreactors and steel...

Sensors for the Biotech & Pharma Industries Featured Systems SFR & SFR vario Shake Flask Reader The SFR Shake Flask Reader and SFR vario offer O2, pH, and OUR monitoring in shake flasks, cultivation tubes, or T-Flasks. While the SFR can be used for simultaneous monitoring in up to 9 flasks, the SFR vario monitors a single vessel and allows additional biomass measurements. Contact us and we find your customized solution! SDR SensorDish® Reader The SDR SensorDish® Reader allows non-invasive, parallel monitoring in 6 or 24 wells. PreSens offers multidishes in low- and deep-well format with...

FEATURED SYSTEMS Fibox 3 LCD trace + Oxygen Probe for In-line Measurement OIM Fibox 4 or pH-1 SMA + Single-use O2 or pH Flow-through Cells + POF The Fibox 3 LCD trace is an oxygen meter for trace oxygen measurements with an analogue interface of 4 – 20 mA. Combined with the oxygen probe for in-line measurements it is the ideal tool for oxygen monitoring in steel bioreactors. The single-use flow-through cells for oxygen and pH measurements can easily be integrated in bypaths or flow systems and allow continuous monitoring. The FTCs are read out with the Fibox 4 and pH-1 mini meters via...

Sensors for the Biotech & Pharma Industries Featured Applications Yeast Culture Monitoring with the SFR vario A model process with S. cerevisiae was performed in 2 L shake flasks with integrated O2 and pH sensors. The SFR vario was applied to monitor oxygen, pH, and biomass during cultivation. The online data gathered with the device was then compared to offline pH and OD values gathered with classic sampling and measurement methods. It delivered accurate data consistent with the classic offline measurements. Additionally, it offered a continuous and detailed view of culture performance...

Process Monitoring in Suspension-adapted CHO Cell Cultures The online measurement of dissolved oxygen concentration and pH in shaken bioreactors enables proper scale down activities from bench-top stirred-tanks to smaller scales. Adjustment of shaking speed as a function of pO2 is now possible, avoiding oxygen limitations at high cell densities. Furthermore, it is possible to detect necessary pH re-adjustments instantly, in order to optimize experiments with shaken bioreactors. Quality Check in Blister Packaging The oxygen microsensor can be used for oxygen measurements in blisters. Septa...