Specifications ■ Micro Infusion Pump iPRECIO® Infusion Method Rotary Finger Method (patented peristalsis) 900 μL Built-in Elastic Reservoir (Medical Grade SIBS) Inner Tubing Material : Medical Grade SEBS (Olefin Series) Inner Diameter : 0.57mm / 0.022in Outer Diameter : 1.22mm / 0.048in / 3.66Fr Length of Outer Tube : approx.135mm Material : Medical Grade SEBS (Olefin Series) Inner Diameter : 0.57mm / 0.022in Outer Tubing Activation Method Sterilized blister package Data Communication Range of Flow Rate Accuracy Battery Life 6 Months at 1.0 μL/hr - 1 Week at 30.0μL/hr EO Sterilized blister package (5pcs / box) ● 5pcs ■ iPRECIO Management System ●iPRECIO Management Software ( requires Windows PC and USB port ) sManagement of Infusion Protocol  Study Name, Number/ID, Date, Experiment Period, Section Name, Operator, Number of Groups/Animals, Animal Species, Strain, Age, Compound Name/ID, Concentration, Buffer Name, Administration Route, etc. sAutomated Recognition of Pump ID/Calibration Factor sPump Programming via-PC  Programmable Parameters Start date/time, Stop date/time, and Flow-rate.  Infusion Mode Selection 1. Instant Infusion Mode 2. Post Recovery (Delayed) Infusion Mode  Flow Rate Mode Selection 1. Constant Flow Rate Mode 2. Variable Flow Rate Mode (maximum : 10 Flow rate steps) ※In Variable Flow Rate Mode, Repeat Mode is selectable.  Dead Volume Setting Catheter diameter / length or Actual volume  Flushing setting Flushing Rate and Exchange Schedule sOff-Line Management of Infusion The iPRECIO® Management System consists of: Data Communication Device USB cable, 2 AAA batteries iPRECIO Management Software Installation CD iPRECIO User Manual Schedule Management (Exchange schedule, Refill date/time, Alarm, Elapsed time & volume infused, etc.) sRe-calibration of iPRECIO pump sUpload of Pump's log ●iPRECIO® Data Communication Device Interface Power Supply Size / Weight Communication with Pump The iPRECIO® is for use in Laboratory Animal Research ONLY. Not for human use. www.iprecio.com E-mail : [email protected] 1-3-25, Koishikawa, Bunkyo-ku, Tokyo, 112-0002 JAPAN Phone: +81-3-3816

The World’s First Totally Implantable, Programmable Micro Infusion Pump for Small Laboratory Animals iPRECIO is an Ultimate Choice ‘‘This implantable infusion pump uses a patented, microprocessor controlled peristalsis mechanism for accurate controlled flow. It is the only implantable and programmable pump for small laboratory animals. iPRECIO can infuse fluids continuously for as long as six months and it can be refilled via a percutaneously accessible port.’’ ® Accurate patented Rotary Finger Method ・ Every pump is factory tested and calibrated Better than ±5% accuracy ・μL/hour to 30.0μL/hour...

The World’s First Totally Implantable, Programmable Micro Infusion Pump for Small Laboratory Animals iPRECIO is an Ultimate Choice ‘‘This implantable infusion pump uses a patented, microprocessor controlled peristalsis mechanism for accurate controlled flow. It is the only implantable and programmable pump for small laboratory animals. iPRECIO can infuse fluids continuously for as long as six months and it can be refilled via a percutaneously accessible port.’’ ® Accurate patented Rotary Finger Method ・ Every pump is factory tested and calibrated Better than ±5% accuracy ・μL/hour to 30.0μL/hour...

Innovative Drug Infusion Technology for Laboratory Animals Implantable The pump can be completely implanted in small laboratory animals subcutaneously. Thus, the animal moves freely without any restrain i.e. tethering） （ during drug infusion. Additionally, infection risk is reduced, and the animal is likely to be significantly less stressed than in a tethered infusion model. Programmable Using the easy to use menu driven iPRECIO software, header information along with infusion protocol details are entered and ultimately downloaded to the pump's flash memory. Start Time, End Time, Flow-rate (1.0μL/hour...

■ Micro Infusion Pump iPRECIO® Infusion Method ■ iPRECIO® Management System ► Management of Infusion Protocol Study Name, Number/ID, Date, Experiment Period, Section Name, Operator, Number of Groups/Animals, Animal Species, Strain, Age, Compound Name/ID, Concentration, Buffer Name, Administration Route, etc. ► Off-Line Management of Infusion Schedule Management (Exchange schedule, Refill date/time, Alarm, Elapsed time & volume infused, etc.) The iPRECIO® Management System consists of: Data Communication Device USB cable, 2 AAA batteries iPRECIO Management Software Installation CD iPRECIO User...