ONE-STOP CIEF AND CE-SDS. ONE-DAY METHOD DEV. RESULTS IN A SNAP. FDA, PDQ

MEET MAURICE™ He’s a real problem solver. Need CE-SDS and cIEF info on mAbs, ADCs and vaccines? Done. He’ll even up you one and get data on their variants. So all that purity, identity and charge heterogeneity data you need for regulatory agencies on your biologic? Maurice hands it over faster than any technique out there. We’re talking FDA, PDQ! Learn more | proteinsimple.

HE’S FLUENT IN CIEF AND CE-SDS. Maurice takes ciEF up a notch, and CE-SDS doesn’t faze him a bit! You’ll get pI and charge heterogeneity data in less than 10 minutes flat — with the added bonus of same-time absorbance and native fluorescence for sensitivity down to 0.7 μg/mL. His size apps give you the high res and wide molecular weight range you need and they’re done in 35 minutes. CE-SDS PLUS Relative Migration Time Charge profile of mAb. 0.25 mg/mL mAb prepared with 4  3–10 Pharmalyte, 10 mM arginine, iminodiacteic acid (IDA) and 2 M urea, pI markers 4.05 and 9.99. % Pre-focused at 1500 V...

HE MAKES IT EASY. Maurice makes everything simple. Just pop in a ready-to-go cartridge, drop in your sample vials or a 96-well plate, and hit start — he does the rest! Handling toxic or sensitive samples like ADCs is a breeze with his on-board sample prep. Switch between both applications as much as you want. There’s no setup or maintenance needed. Did we mention there’s no cross-contamination either? Learn more | proteinsimple.co

HE’S A TIMESAVER. Maurice helps you develop assays fast so you get to real results even faster. Your cIEF and CE-SDS methods are done in a day. He’ll knock weeks or even months off your development timelines, and you do it all on one system to boot. The icing? You can develop platform methods and use them for multiple molecules too. METHOD DEV TIME (CE-SDS OR CIEF)

HE’S DEPENDABLE. Get CVs under 4  day in and day out. Your data is reliable no matter what — across samples, assays, users, instruments or labs. % Not to mention Maurice analyzes your data automatically and tweets you when results are ready! Plus, he’s got all the tools you need for 21 CFR Part 11 compliance and traceability. cIEF assay performance over 100 injections with peak area CVs consistently less than 4  . 0.25 mg/mL mAb prepared with 4  3–10 Pharmalyte, 10 mM arginine and % % iminodiacteic acid (IDA), pI markers 4.05 and 9.99.

SPECIFICATIONS SYSTEM cIEF Charge Application CE-SDS Size Application Absorbance Detection Fluorescence Detection Onboard Mixing for Sample Prep cIEF SPECIFICATION CE-SDS SPECIFICATION Minimum Sample Volume Sample Delivery Typical Separation Time Detection Capability Typical Voltage Sample Injections per Cartridge 100 guaranteed, 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS Maximum Sample Injections per Batch pI/Size Range Relative Migration Time CV pI/Sizing Resolution 0.05 pI units (for wide range 3–10 ampholyte) Dynamic Range 0.7 µg/mL (Native fluorescence) 3.0 µg/mL (Absorbance) (Values...

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