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Everyone whose life cancer touches feels the urgency for better therapies. To a person diagnosed with cancer, the future is now. The battle against cancer is also a race against time. BSD hyperthermia systems help the human body win this fight giving physicians the edge over monotherapies. We offer a range of complete solutions allowing for individualized treatment. What is the Benefit of Hyperthermia? Hyperthermia - heating the tumor to 40 - 45 °C - combined with radiation and/or chemotherapy is a proven treatment for malignant tumors. Randomized clinical trials have shown that...

Proven in hospitals worldwide Haukeland Sykehus, Bergen, Norway Erasmus University, Daniel den Hood Cancer C, Rotterdam, Netherlands H.- Heine University, Pediatric Oncology, Dusseldorf, Germany LMU University, Klinikum GroBhadern, Munich, Germany Humboldt University, Charite Medical School, Berlin, Germany North Carolina West Virgina Asia / Australia Cancer won't wait

What is the Advantage of 3d Hyperthermia? 3d hyperthermia allows for optimum results, since the heating zone is targeted specifically at the tumor region. This is achieved by focusing the electromagnetic power onto the target volume. The focus is not fixed at the center of the applicator but may be targeted at any specific area, providing the system operator with significantly more freedom in positioning the applicator. The BSD 20003d hyperthermia system is designed particularly for treating tumors

Improved treatment with targeted heating To begin with, part of the patient's body is enclosed by an eye-shaped applicator. Phase and amplitude steering can be used to create the heating focus within the applicator. The 3d technology makes use of 24 dipole antennas driven by 12 RF power channels. These dipoles are arranged in three rings of eight antennas each. By varying the phase and amplitude of each of the 12 input channels, the operator creates a constructive interference at the tumor zone. The dedicated treatment-planning software, HyperPlan, calculates the best possible settings for...

Combined Treatments mith Clinical studies have revealed that the addition of hyperthermia to radiotherapy can double the This is because the temperatures attained through hyperthermia increase blood flow to the tumor, accentuating the formation of the oxygen radicals required to attack cancer cell DNA through radiotherapy. Heat shock through hyperthermia is also an effective agent in inhibiting DNA repair in cancer cells after double-strand breaks occur from ionizing radiation. Further, hyperthermia kills radiation-resistant hypoxic cancer cells by forcing a rise in their anaerobic...

time (month) Pelvic Tumors (Cervix / Rectum / Bladder) "Complete-response rates were 39% after radiotherapy and 55% after radiotherapy plus hyperthermia. The duration of local control was significantly longer with radiotherapy plus hyperthermia than with radiotherapy alone. 3-year overall survival was 27% in the radiotherapy group and 51% in the radiotherapy plus hyperthermia group."

Let clinical studies speak for themselves Cervical Carcinoma "... was well tolerated and did not significantly add to either the relevant clinical acute or long-term toxicity over radiation alone. A complete response was achieved in 50% in the radiotherapy group versus 80% in the thermoradiotherapy group. The 3-year local relapse-free survival of the patients who were treated with thermoradiotherapy (79.7%) was significantly better than that of the patients treated with radiotherapy (48.5%)." International Journal of Hyperthermia 2001, Vol. 17:97 -105 Rectum Carcinoma "Preoperative...

Clinical Results Soft Tissue Sarcomas "Response to neoadjuvant chemotherapy combined with regional hyperthermia is predictive for an improved local tumor control resulting in a long-term survival benefit for patients with high-risk soft tissue sarcomas at unfavorable retro- peritoneal or visceral sites." Journal of Clinical Oncology 2002, Vol. 20:3156 - 3164

Let clinical studies speak for themselves Prostate Cancer "... patients with symptomatic, locally advanced, previously irradiated hormone refractory prostate cancer were treated with further radiation and external hyperthermia. All patients had complete resolution of symptoms lasting for 12 - 24 month. At most recent follow-up, no patient has experienced significant treatment-related side effects. In these patients with no other therapeutic alternatives, re-irradiation and hyperthermia can provide durable tumor response for more than a year, resulting in significant improvement in quality...

Sigma Treatment Base Unit The Sigma Treatment Base Unit includes both patient and applicator support systems. The patient support system consists of two fiberglass rods that support a mesh sling, which is connected in turn to the hydraulic lift assembly, located at both ends of the patient support system. The patient is placed on the sling in preparation for the therapy, then the applicator is positioned over the tumor area and the water bolus filled. A large water reservoir mounted in the base unit maintains the bolus water at the desired temperature throughout the treatment. Dodek...

Computer System The entire BSD 20003d hyperthermia system is controlled by a PC, running under Windows® 2000 Professional, interfaced to all system modules. A large, user-friendly LCD color monitor, cordless keyboard and cordless mouse create an ergonomic operating environment. The system also includes a high-resolution color inkjet printer for instant hardcopy treatment reports. The system software incorporates a color Graphic User Interface, automatically guiding the operator through the set-up and treatment procedures and featuring menu-driven selection of treatment parameters.

The Sigma Eye applicator is the standard tor 3d conformal treatments. It is based on the latest, well-proven phased-array technology and includes an integrated water bolus for energy coupling, surface cooling as well as fast and easy patient setup. It takes its name from the eye-shaped water bolus surface that minimizes the bolus pressure on the patient. The 24 paired antenna arrays are mounted in three rings of 8 dipoles each and are driven by the 12-channel generator. By adjusting the amplitude and phase of each channel, the electromagnetic energy can be focused three-dimensionally onto...