Human Pneumococcal Igg (9-Plex)

Product catalog summary

Overview: The Q-Plex™ Human Pneumococcal IgG (9-Plex) is a chemiluminescent multiplex ELISA designed to measure antibody levels against serotypes in the Pneumovax®23 vaccine. It operates on a 96-well plate format.

Principle of the Assay: This assay detects antibodies targeting the polysaccharide capsule of S. pneumoniae in a serotype-specific manner, crucial for protection against pneumococcal disease. The assay is indirect and measures nine different serotypes.

Performance and Validation Data: The assay's precision is evaluated with intra-assay and inter-assay replicates, showing variability percentages for each serotype. Key performance metrics include:

Calibrator Range: Varies per serotype, e.g., 2.46 - 0.00337 μg/mL for serotype 2.
Upper and Lower Limits of Quantification (ULOQ and LLOQ): Specific to each serotype, indicating the assay's sensitivity.
Limit of Detection: The minimum detectable concentration, e.g., 0.00169 μg/mL for serotype 2.
Precision: Inter-assay and intra-assay precision percentages are provided, e.g., 10% and 12% for serotype 2.
Linearity: Average linearity is around 101% across serotypes.

Company Information: Quansys Biosciences, based in Logan, UT, is ISO 9001:2015 and ISO 13485:2016 certified, ensuring compliance with GMP. The company emphasizes quality management in its product development and manufacturing processes.

Contact Information: For inquiries, Quansys can be reached via phone, fax, or through their website.

Catalog excerpts

The Q-Plex™ Human Pneumococcal IgG (9-Plex) is a chemiluminescent multiplex ELISA run on a 96-well plate.

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Principle of the Assay The Q-Plex™ Human Pneumococcal IgG (9-Plex) is a chemiluminescent multiplex ELISA run on a 96-well plates that measure antibody levels corresponding to the serotypes found in the Pneumovax®23 vaccine. Antibodies play an essential role in the protection against pneumococcal disease. In humans, serum antibodies typically act against the polysaccharide capsule in a serotype specific manner. There are multiple vaccination options for protection against S. pneumoniae, with the major difference being the number and composition of specific serotypes present in the vaccine. Performance...

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