Introduction
The Cardiac Risk Prediction Array is a comprehensive tool for assessing genetic risk for Coronary Heart Disease (CHD). It combines genetic data with common risk factors to provide a more accurate risk assessment.

Algorithm and Genetic Risk Score
The array utilizes Genome Wide Association Studies (GWAS) findings, requiring genotyping of 19 CHD 'at risk' SNPs. A rapid array developed by Randox allows simultaneous genotyping, reducing time and cost. The genetic risk score is calculated using an algorithm that weights each SNP and combines it with common risk factors to determine overall CHD risk.

Common Risk Factors
Traditional risk assessment tools like PROCAM and Framingham have low predictive value and do not account for genetic predisposition. The Cardiac Risk Prediction Array addresses this gap by integrating genetic data.

Protocol
The process involves four steps: extraction of genomic DNA, amplification via multiplex PCR, hybridization to a biochip array, and detection using the Evidence Investigator analyser. This streamlined protocol allows for genotyping within one day.

Benefits
The array provides a rapid, reliable method for genetic risk assessment, allowing for better classification and targeted preventative actions. It also identifies patients at risk for statin-induced myopathy, aiding in personalized treatment decisions.

Laboratory Advantages
The array supports simultaneous genotyping of 19 SNPs, with a simple protocol optimized for molecular laboratories. It processes 36 patient samples per kit and offers easy result interpretation with dedicated software.

Evidence Investigator
This semi-automated biochip analyser enhances laboratory efficiency through multiplexing, reducing time and costs associated with multiple tests. It includes features for result traceability and extensive quality control.

Ordering Details
The Cardiac Risk Prediction Array is available in packages of 72 biochips, with the Evidence Investigator Analyser sold separately. Note that extraction reagents are not included.