Evidence Investigator Multiplexing... Proven, Perfected, Evolved The first biochip analyser for protein and molecular arrays

Evidence Investigator Versatile, efficient and comprehensive testing The Evidence Investigator offers complete patient profiling with the most comprehensive test menu on the market. Consolidates immunoassay and molecular diagnostics on a single platform with protein and DNA biochips. The Evidence Investigator is a compact, semi-automated bench top platform applicable in a wide range of settings including: • harma and drug development: Pre-clinical and clinical P studies • Private/Public sector research applications Utilising revolutionary Biochip Array Technology, • Environmental laboratories...

The Evidence Investigator package Barcode scanner Biochip carrier handling tray Biochip imaging module The washing procedure is quick and easy and is performed using a wash bottle. Biochip carrier loaded into Evidence Investigator Discrete test sites on each biochip for individual analytes Image processing Signal reagent is added to each biochip before imaging. The light signal generated from each of the discrete test regions on the biochip is simultaneously detected. The analyser uses unique image processing software to translate the light signal generated from the chemiluminescent reactions...

Why Evidence Investigator? Industry leading technology for high quality results Save time - save costs • ultiplex testing allows multiple tests to M be carried out from a single patient sample r educing the amount of time and labour spent on individual tests Consolidation on one system • he world’s first platform allowing consolidation T of immunoassay and molecular diagnostics with protein and DNA based biochips • reating cost savings and improving C laboratory efficiency World’s most diverse test menu • ore tests available than any other M sole supplier • outine and novel markers available...

Reduced sample volume • Analyse a complete profile of biomarkers from as little as 25µl of sample • Ideal for paediatric testing • Saves patient distress High throughput • he Evidence Investigator has the ability to T process 630 tests in 70 minutes using the protein arrays • t can also detect up to 23 mutations, SNPs I or pathogens in as many as 54 samples at once, in as little as three hours for molecular applications Quality results • nter and intra-assay CV’s typically less I than 10% • xtensive QC capabilities with multi-analyte E controls and calibrators available • ser defined reference...

Unit Selection View Operators Array Selection ^indJ^Jjjrjr^bisjl Array \\. Cardiac Array Cytokine Array Drug:; 'j'AhjUsri I f'Jrln^j : Sample Entry s Enter Carrier Details Sample Carrier Data Entry Carriers far worklist complete. Batch Details^ [Please Enter Batch Details Carrier Details Accept Carrier WorkList: 'swTest' | Carrier Ho | Array Name | Well | Sample Code | Type | D Factor * WorkList Array Sample Entry screen

On-board data analysis • o manipulation of results required N • educes the scope for operator error R • apid results improves workflow R Extensive QC capabilities • nternal QC software included with Levey Jennings charts I multi-point QC rules and auto flagging of outliers Connectivity • IMS integrated for convenient reporting L Results History screen Retrospective testing • llows the user to retrieve previously unreported tests A • Reduces reagent wastage • Saves time and labour costs Highly secure • assword protected for various user levels P • ull traceability of data F Simplicity • Minimal...

Molecular Arrays Randox Molecular Diagnostics (MDx) offers a range of molecular arrays and assay formats, providing diagnostic, prognostic and predictive solutions for a range of conditions including sexually transmitted infection, respiratory infection, coronary heart disease (CHD), familial hypercholesterolemia and colorectal cancer with many more applications currently in development. The versatility of the Randox multiplex PCR and proprietary Biochip Array Technology is exemplified by the broad range of array formats available. Molecular Array Protocol Outline Step 1 Extraction DNA/RNA extracted...

Benefits of the Respiratory Pathogen Array • emi-quantitative testing – allowing determination of primary S infection • omprehensive profile of pathogens identifies secondary or C multiple infections which may otherwise remain untreated • Rapid turnaround time of five hours • ay prevent the spread of infection through early and more M appropriate intervention • ay reduce antibiotic misuse M • educed sample requirement – of particular relevance to young R and infirm patients • ompatible with various sample matrices C • ncreased specificity through biochip hybridisation I • patial separation on...

Immunoassay Arrays Highly accurate testing • BAT has a proven high standard of accurate test results with CV’s <10% • Multiplex analysis minimises analytical variation between tests Better patient diagnosis • esting for multiple markers simultaneously T increases the amount of patient information rapidly available to the clinician, allowing for more informed patient diagnosis Assay formats Protein / Antibody assay formats Competitive immunoassay In a competitive immunoassay, the more analyte present in a sample, the less labelled conjugate that will bind to the immunoreaction site. Therefore...

Multiple sample types • ultiple sample types can be used on one M analyser including serum, plasma, whole blood, urine, oral fluid and alternative matrices • his allows the clinician to offer flexible patient T testing Enzyme labelled antibody (conjugate) Discrete test regions Analyte in patient sample Antibody bound to biochip surface Biochip Sandwich immunoassay Result traceability • ar-coded biochips and patient samples B ensure complete traceability of results Retrospective reporting • etrieve previously unreported results R without additional testing, saving time Wide and varied test menu...