RECREATING THE NATURAL WOUND HEALING ENVIRONMENT ActiGraft is a patented coagulation formula that rapidly transfers the patient’s own blood into a powerful whole blood topical dressing reactivating the natural healing cascade. ActiGraft continuously promotes wound healing for 7 days with 1 application weekly. ActiGraft is effective on: • Vascular Wounds • Skin Tears • Diabetic Foot Ulcers • Post-surgical Wounds • Pressure Injury Wounds PATIENT: 98 year-old, white male with congestive heart failure, atrial fibrillation (long-term coumadin), vitamin D deficiency, malnourishment and anemia, venous stasis disease. LABS & DIAGNOSIS: Lab results collected in December 2018 detailing H/H 8.9/31.5, albumin 2.4. Patient diagnosed with stage 4 right heel, chronic osteomyelitis, right foot and ankle. WOUND HISTORY: • Admitted after hospitalization for L femure fracture • 8 month-old ulcer • Boggy heels assessed upon admission • DTI injury developed into a Stage 4 with exposed bone • MRI showed osteomyelitis • ID consult with no further Anbx recommended PAST TREATMENTS: Santyl and mesalt, VAC, optifoam, puracol, iodoform and dry dressing with chrushed Flagyl for odor, VAC. OFFLOADING: Heel offloading boots worn 24/7; the patient was in his wheel chair for most of the day. ACTIGRAFT TREATMENT PROGRESSION:

74 year-old, white male with congestive heart failure, atrial fibrillation (long-term coumadin), vitamin D deficiency, malnourishment and anemia, venous stasis disease. LABS & DIAGNOSIS: Lab results collected in December 2018 detailing H/H 8.9/31.5, albumin 2.4. Patient diagnosed with stage 4 right heel, chronic osteomyelitis, right foot and ankle. WOUND HISTORY: • Admitted to LTC 4.14.18 after hospitalization for L femur fracture • 19 week old ulcer • Boggy heels assessed upon admission • DTI injury developed into a Stage 4 with exposed bone • MRI showed osteomyelitis • ID consult with no further...

CASE STUDY 3 PATIENT: 67 year-old, paraplegic male. PAST MEDICAL HISTORY: DM2, Neuropathy, HTN, HPL, Anemic, OA. LABS Labs 5/30/14 - HbA1C 8.6, RBC 4.21, HGB/HCT 37, Platelet 92, PTT 22.9. WOUND HISTORY: • Diabetic Ulcer 2A right medial foot • 89 week-old ulcer • 2.60 cm2 X 0.3 cm, draining small amounts of serous/ sanquinous • ABI results for the affected leg = 0.90 PAST TREATMENTS: Wet-to-dry, foam, silver alginate, antibacterial agents, HBO. OFFLOADING: Wheel chair bound.

77 year-old, white male. PAST MEDICAL HISTORY: DM2, Neuropathy, PVD, Gout, Afib, HTN, HPL, OA, History of smoking/15 pack years. V=Weekly Application WOUND HISTORY: • Diabetic Ulcer 2A right medial foot, onset • 30 week-old ulcer • 3.96 cm2 X 0.5 cm, moderate amounts of serous/ PAST TREATMENTS: Wet-to-dry, foam, silver alginate, Anbx agents, HBO, skin graft, skin substitute, regular surgical debridement. sanquinous drainage • ABI results for the affected leg = 1.11 ACTIGRAFT TREATMENT PROGRESSION: Day 0 To learn more about ActiGraft, please visit www.reddressmedical.com. RedDress USA 822 A1A...