RENISHAW. apply innovation™ neuro I mate® - key features About neuromate® • The first certified image-guided neurosurgical robot to be used in the world • Designed specifically for neurosurgery and can be used for neuro-endoscopy, stereoencephalography (SEEG), deep brain stimulation (DBS), biopsy and several other applications • Estimated at over $30 million R&D investment to date1 • Renishaw is a world leader in precision engineering • Installed systems in several countries worldwide Surgical applications • Stereotactic neurosurgery procedures • DBS • Biopsy • Implantation of depth electrodes for epilepsy monitoring (SEEG) • Motor cortex stimulation (MCS) • Neuroendoscopy And many other research applications System benefits • Complete procedure solution • Procedure specific modules / tools • Comprehensive surgical planning / navigation system • C-arm, O-arm & X-ray interfaces • 2D - 3D registration • Frameless & frame-based support (all standard frames) • Time saving in multiple trajectories • Compact, easy to transport and easy to clean • Designed for quick parts replacement • Quick to set up and operate • On-board system diagnostics • Customisable • Dimensions • Frame adaptors • Imaging modalities • Powered tool holders for standard or custom tools • Strong international clinical support team • The neuromate robot has been used for over 20 years in the clinical field for an estimated 10,000 procedures2 • Anti-collision system • Constant accuracy checking with redundant encoders • Safety line constantly monitoring the status of mechanical and electrical components • Remote control with safety trigger • Non-backdrivable joints with no backlash ensure immediate, stiff mechanical locking in case of error condition or power outage • Full image guidance during planning and operation As a replacement for the targeting arc of a stereotactic frame or for a tracking system, neuromate® offers the following safety benefits: • Regular calibration ensures system remains within accuracy specifications • Reduced risk of invisible mechanical damage or wear (compared to a stereotactic frame arc) • No need for error-prone writing down or setting of target co-ordinates • Stable mechanical attachment (compared to a stereotactic frame or clamping systems used

New Mills, Wbtton-under-edge, Gloucestershire, GL12 8JR United Kingdom apply innovation™ Planning and navigation software (IVS Technology VoXim®/neuromate®) General features • Medical image analysis software • Neurosurgical planning software • For stereotactic frame • For neuromate® system • Neurosurgical execution and navigation software • For neuromate® system DICOM import • DICOM import • Data import from DICOM files • CT and MRI data supported • CT gantry tilt supported X-ray import • Import of image files • Direct scanner acquisition • With localizer plates • With...