Take Control of Your UF/DF Process KrosFlo® KR2i RPM™ System Tangential Flow Filtration System with In-Line Protein Concentration Management Finally, a Tangential Flow Filtration (TFF) system that monitors concentration during your UF/DF run. No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time: your concentration. With the power of the KrosFlo® KR2i Automated TFF System and the insights from the CTech™ FlowVPX® System, you can take control of your process. • Strengthen your process control with high accuracy and reproducible results. Increase process efficiency by reducing cycling time and increasing yield throughput. Reduce process risk by ensuring accurate concentration throughout the TFF process. To learn more, visit our website: www.repligen.com/kr2i-rpm © 2023 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation or a Repligen affiliate, or their respective owners. | DOC0292 eRev. 03

KrosFlo® KR2i RPM™ System POWER OF AUTOMATION Walk-Away Automation — 13 automated process control modes and manual operation to meet your PD needs. Robust processing allows for processing of volumes from 10 ml–10 L to meet both lab and clinical production requirements. Enables lowvolume, high-concentration applications. Minimize risk with fully enclosed ProConnex® custom flow paths, as part of the automated TFF process. Flexible Configuration — Compatible with flat sheet cassettes and hollow fiber filters with plug-n-play accessories for ultimate flexibility. Customizable flow path and small...

KrosFlo® KR2i RPM™ System INTEGRATED DATA ANALYSIS Real-Time Process Management Software (KrosFlo® RPM™ Software) Integrated software combines the power of the KR2i automation with the real-time insight from the FlowVPX System to give you the data you need and the control you’ve desired. • TFF automation control based on in-line concentration Provides real-time overview at every step of the filtration process Automatically graphs data and trends of critical inputs and outputs Flexible plug-and-play technology for custom needs Better Insights to Drive Better Outcomes By leveraging in-line concentration...

With in-line concentration data as the primary control factor for the UF/DF run, the process was able to reach target final concentration regardless of starting volume, crossflow rate, TMP, or retentate hold-up volume. To learn more, visit our website: www.repligen.com/kr2i-rpm