PATsmart™ FlowVPX® In-line System Specification Sheet

Product catalog summary

Overview
The PATsmart™ FlowVPX® System is designed to monitor and optimize critical process parameters in real-time, enhancing product consistency and quality. It uses Variable Pathlength Spectroscopy for direct concentration measurement, eliminating the need for dilution and background correction. The system is adaptable for various sample types and concentrations, suitable for lab, pilot, and production-scale operations such as UF/DF, chromatography, mixing, and fill-finish.

Light Sources
The system can be paired with the Agilent Cary 60 or PATsmart Beams™ System light sources. The Agilent Cary 60 is ideal for process development and research, offering spectral scans and measurements between 190 and 1100 nm. The Beams System is designed for GMP environments, targeting molecules at 260 nm or 280 nm, with a compact design and IP65 rating.

Features and Benefits

Measurement Method: In-line measurements using Variable Pathlength Technology for real-time readings without dilution.
Construction: Robust stainless steel design.
Flow Cells: Connects via various fittings; two included with the system.
Linear Range-Finder Technology: Automatically identifies the linear region of absorbance data.
Integration Options: Two analog output channels.
Software: PATsmart ViPER® ANLYTX Software with OPC UA communication and optional 21 CFR part 11 compliance.
Education/Support: On-site installation and training included.

Specifications

Qualification Slope Range: 0.10 Abs/mm to 46 Abs/mm.
Qualification Slope Repeatability: ≤2% RSD.
Maximum Pathlength: 5.000 mm.
Minimum Pathlength Step: 0.001 mm.
Housing Material: 316L Stainless Steel.
Dimensions: 120 x 100 x 230 mm.
Weight: 3.2 kg.
Computer Specifications: Minimum Intel i5 processor, 250 GB hard drive, 8 GB RAM, Windows 10 or 11.
Power Requirements: 100–230 VAC, 50–60 Hz; 24 VDC, 0.6 A Max Current Draw.
Operating Conditions: 0°C to 48°C, 15 to 80% Relative Humidity.
Compliance: CE, IP65, Pollution Degree 2, RoHS.

Customer Service
Repligen offers comprehensive support from predelivery through installation and training, including IQOQ, on-site training, and a 12-month warranty. Service contract options and Computer System Validation (CSV) are available.

Disclaimer
Repligen disclaims liability for incidental or consequential damages related to the use of the system. Specifications are subject to change without notice.

Catalog excerpts

PATsmart™ FlowVPX® In-line System Specification Sheet-1

PATsmart™ FlowVPX® System Product Specifications Specification Sheet Part ID: SYS-FX-VP-CARY60 (FlowVPX with Agilent Cary 60) SYS-FX-VP-BM (FlowVPX with Beams™ System) Overview The PATsmart™ FlowVPX® System enables users to monitor and optimize critical process parameters and make real-time decisions for enhanced product consistency and quality. The system uses Variable Pathlength Spectroscopy to measure concentration directly, avoiding costly, time-consuming dilution and background correction steps. The in-line design also enables feedback in real time without removing material from the process or introducing additional sources of error. The system is adaptable to a wide range of sample types and the highest concentrations found in the biopharmaceutical industry. It can support lab-scale, pilot-scale, and productionscale fluid systems, making it suitable for operations such as UF/DF, chromatography, mixing, and fill-finish. Directly incorporating the FlowVPX System into one or more operations in a process stream helps to increase efficiency and reveal process characteristics previously hidden when using fixed pathlength sensors, which often oversaturate. Light Sources Built for flexibility, the FlowVPX instrument can be paired with the Agilent Cary 60 or PATsmart Beams™ System light sources. The Agilent Cary 60 spectrophotometer is the optimal light source for process development and research settings, where there is a need for taking spectral scans and singlewavelength measurements between 190 and 1100 nm. The Beams System is designed for GMP environments targeting molecules at 260 nm or 280 nm. It has a compact design and an IP65 rating for compatibility with cleaning requirements. © 2026 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners. | DOC0206 eRev. 5.0 16

Open the catalog to page 1

PATsmart™ FlowVPX® In-line System Specification Sheet-2

Specification Sheet FlowVPX System

Open the catalog to page 2

PATsmart™ FlowVPX® In-line System Specification Sheet-3

Specification Sheet PATsmart™ FlowVPX® System FlowVPX System Specifications Min Processor: Intel i5 (i7 preferred) Computer Specifications Min Hard Drive: 250 GB (SSD preferred) • Requires GMP-grade cart for use in • RoHS manufacturing environment

Open the catalog to page 3

PATsmart™ FlowVPX® In-line System Specification Sheet-4

PATsmart™ FlowVPX® System Specification Sheet Final application suitability of all materials and ratings are the sole responsibility of the user. Specified pressure and temperature ratings may be subject to limitations. Contact a Repligen analytical representative for more information. More information Repligen Corporation and/or its affiliates, to the extent allowed by law, disclaims, and in no event shall be liable for, any incidental or consequential damages in connection with user, instrument, or system performance in relation to all content contained in this document, including but not limited...

Open the catalog to page 4