REBEL® XT System Product Specifications Data Specification Sheet Part ID: 850-00109 Overview The REBEL® XT System is the latest evolution in at-line cell culture media analysis, designed to empower upstream bioprocessing teams with fast, actionable data—right at the bench. Compact and self-contained, the REBEL XT analyzer puts control directly in the user’s hands, delivering results in approximately 15 minutes with minimal setup and no need for external labs or specialized operators. Built on a foundation of proven performance and refined through years of customer feedback, the REBEL XT analyzer introduces a series of hardware and software enhancements that improve reliability, analytical power, and user experience. The system leverages advanced microfluidic technology and integrated signal processing to provide real-time, quantitative analysis of 22 critical media components—including 19 amino acids, 2 dipeptides, and choline—requiring as little as 10 µL per sample. Each result is automatically calibrated, verified for performance, and delivered as a clear concentration value—eliminating the need for manual data processing. Engineered for ease of use and high-throughput demands, the REBEL XT unit sits directly on the benchtop and pairs with the REBEL SMArt® Kit, an all-in-one consumable set that simplifies sample preparation and ensures robust, repeatable quantitation. Designed for seamless deployment from early development through GMP support, the REBEL XT System integrates easily into existing workflows and supports data visualization and multivariate analysis tools to deepen insight into nutrient dynamics, feed strategy optimization, and critical quality attributes (CQAs). Whether your focus is on protein production, cell and gene therapy, or media development, the REBEL XT System enables smarter decisions faster— minimizing risk, accelerating timelines, and improving yield and quality. repligen.com © 2025 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners. | DOC0419 eRev. 2

Data Specification Sheet Features | Benefits Fast Turnaround Quantitative results in ~15 minutes per sample for 22 key analytes. At-line Convenience Compact, self-contained system designed for benchtop analysis without outsourcing delays.

Data Specification Sheet Customer Support Options Repligen is committed to customer success from predelivery through installation and training. Included with purchase: Supp°rt and Training • Full 12-month warranty support • Post-obsolescence hardware support • Software support Available as additional options: Available Options • Single- and multi-year service contract options, which include annual PM service • Preventative Maintenance (PM) service options Final application suitability of all materials and ratings are the sole responsibility of the user. Specified pressure and temperature ratings...