1. Catalogs
  2. Repligen
  3. PATsmart™ ZipChip® System Brochure
video corpo

PATsmart™ ZipChip® System Brochure

PATsmart™ ZipChip® System Brochure

PATsmart™ ZipChip® System Brochure

Product catalog summary
Overview: The PATsmart™ ZipChip® platform by Repligen is designed to accelerate mass spectrometry (MS) characterization through rapid protein characterization and metabolomic analysis using microfluidic technology. It offers efficient separations of complex samples in a fraction of the time compared to traditional liquid chromatography (LC).
Key Features:
  • Biological Characterization: The platform prepares and separates biological samples, electrospraying them into mass spectrometers for analysis. It provides better separation quality quickly, supporting biotherapeutic, metabolomic, and proteomic applications.
  • Sample Integrity: Gentle sample preparation preserves protein structure, eliminating the need for detergent removal or desalting, resulting in cleaner mass spectra.
  • Microchip Technology: Integrates capillary electrophoresis (CE) and electrospray ionization (ESI) without junctions or dead volumes, ensuring high analytical quality and repeatability.
Applications:
  • Metabolomics: Enables detection, identification, and quantitation of small polar analytes from various matrices, with results ready in minutes.
  • Protein Characterization: Offers streamlined workflows for Charge Variant Analysis, Rapid Intact Mass Analysis, Subunit Analysis, and Peptide Mapping.
  • Oligonucleotides: Provides advantages over LC separations for nucleic acid-based drugs, avoiding contamination from ion-pairing agents.
  • Small Molecules: Facilitates fast analysis with simple dilution and shooting, requiring no labeling or derivatization.
Operational Process: Users select an application, chip, and kit, load the premixed background electrolyte and sample, and run the process. The system automatically loads, separates, and electrosprays samples, with integrated software cueing the mass spectrometer for analysis.
Conclusion: The ZipChip® platform enhances bioprocessing efficiency, offering rapid and reliable analysis for a range of biological and chemical samples.
See more

Catalog excerpts

PATsmart™ ZipChip® System Brochure-1

Accelerate your MS Characterization Rapid protein characterization and metabolomic analysis with microfluidic technology for highly efficient separations of complex samples.

 Open the catalog to page 1
PATsmart™ ZipChip® System Brochure-2

Repligen Enabling Advanced Bioprocessing Biological Characterization in Minutes Give your mass spec some zip The PATsmart™ ZipChip® platform prepares and separates a wide range of biological samples, then electrosprays them into your mass spec for analysis. Just clip it on. The process takes as little as a few minutes, and it results in better separation quality than most LCs in a fraction of the time. Simple workflows and multiple kit options cover a host of biotherapeutic, metabolomic, and proteomic applications. Native Conditions Main Peak Easy on samples ZipChip plays well with your mass...

 Open the catalog to page 2
PATsmart™ ZipChip® System Brochure-3

Repligen Enabling Advanced Bioprocessing Efficiency with Advanced Microchip Technology “With ZipChip, you get the data faster, and because of that, you can make quick decisions” —Associate Scientist at Amgen Efficient separations Pick an application, a chip, and a kit. After loading the premixed background electrolyte and sample into the autosampler, pop in a ZipChip and hit run. Use vials or 96-well plates. It’s hands-off from there. Smart chips tell the system which method to use based on your preferences. Samples are automatically loaded, separated, and electrosprayed. Integrated software...

 Open the catalog to page 3
PATsmart™ ZipChip® System Brochure-4

Repligen Enabling Advanced Bioprocessing Protein characterization ZipChip is a one-stop shop for CQAs— with streamlined CE-MS workflows for Charge Variant Analysis of basic and acidic species, Rapid Intact Mass Analysis, Subunit Analysis, and Peptide Mapping for deeper characterization. Detect, identify, and quantitate small polar analytes from a variety of matrices, like cell lysates or growth media, and monitor dynamic levels of metabolites in real time. Sample prep is quick and easy, and results are ready in minutes. Oligonucleotides The characterization of nucleic acid-based drugs like oligonucleotides...

 Open the catalog to page 4
PATsmart™ ZipChip® System Brochure-5

Boost your bioprocess today! © 2026 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners. ZipChip is subject to export controls including those of the Export Administration Regulations of the U.S. Department of Commerce, which may restrict or require licenses for the export of product from the United States and their re-export to and from other countries. | DOC0436 eRev. 2.0 26 Jan 2026 Repligen Corporation | www.repligen.com | [email protected]

 Open the catalog to page 5
*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.
About MedicalExpo
MedicalExpo is a marketplace that offers B2B players a complete experience, from product sourcing to purchase. MedicalExpo is an entity of VirtualExpo Group.