AVENIO NGS Oncology Assays Comprehensive genomic profiling (CGP), targeted profiling, and surveillance & monitoring of solid tumors for clinical research. For Research Use Only. Not for use in diagnostic procedures.

A versatile solution to meet your research needs AVENIO NGS Oncology Assay kits provide researchers a versatile solution for tumor tissue and ctDNA analysis with an integrated end-to-end workflow. With accurate and reliable analysis of ultra low ctDNA detection as well as formalin-fixed paraffin-embedded (FFPE) tissue samples, AVENIO NGS Oncology Assays offer laboratories in-house tumor profiling, comprehensive genomic profiling (CGP), and surveillance & monitoring. Each kit includes reagents for DNA extraction, sample input QC (for tissue), library preparation, target enrichment, robust bioinformatics,...

Example research use cases Example A Comprehensive genomic profiling Assess 324 cancer-relevant genes plus TMB, MSI and LOH in a single panel that is designed to match the genomic content of FoundationOne® CDx panel First line Second line Example B Targeted Kit Tumor profiling Identify biomarkers in NCCN Guidelines1 Expanded profiling First line Second line Surveillance Kit Monitor tumor burden longitudinally in lung cancer and colorectal cancer Longitudinal tumor burden monitoring * Expanded profiling First line Second line Surveillance Kit Surveil for minimal residual disease in lung cancer...

Performance you expect from Roche and Foundation Medicine AVENIO Tumor Tissue CGP Kit: Analytical variant detection performance across genomic alterations and signatures Libraries were prepared from 314 FFPE-derived DNA samples by the AVENIO Tumor Tissue CGP kit. For each alteration classification, the percentage of expected variants that were detected by the AVENIO Tumor Tissue CGP kit are shown. For genetic signatures, the percentage of expected samples detected as MSI, TMB, and LOH high assessment are shown. Classification Detected Variants/Signatures Short Variants Exceptional Performance...

An integrated solution for an end-to-end hybrid-capture workflow The efficient, high-quality AVENIO workflow includes all sample prep reagents, input QC (tissue only), robust bioinformatics and secondary analysis all from single trusted source. It has been optimized to minimize hands on time, and deliver high-quality results in just 5 days, making it easy for you to obtain reliable genomic insights about solid tumors in your lab. 5 day workflow from DNA isolation to data analysis Day 1 DNA Isolation Target Enrichment Analysis & Report AVENIO Tumor Tissue Analysis Kits V2 AVENIO Tumor DNA Isolation...

Exceptional performance1 Rigorously optimized using thousands of samples, AVENIO assays deliver the level of performance you expect from Roche, a world leader and trusted partner in oncology. AVENIO Tumor Tissue Analysis Kits V2 Mutant Allele Frequency/ Copy Number AVENIO Tumor Tissue Kit V2 Sample dependent Sample dependent Sample dependent Samples: FFPE tissue curls/sections, DNA input: ≥20 ng of FFPET DNA, total DNA amount for each sample determined by input QC. Sensitivity and Positive Predictive Value (PPV metrics based on observed product performance. Sensitivity and PPV performance reported...

For Research Use Only. Not for use in diagnostic procedures.

Bring the power of Roche and Foundation Medicine* into your lab Contact your Roche representative today Proven Technology Comprehensive Portfolio Trusted Expertise For Research Use Only. Not for use in diagnostic procedures. *for the AVENIO Tumor Tissue CGP Kit only. © 2023 Roche Sequencing Solutions, Inc. All rights reserved. AVENIO is a registered trademark of Roche. FOUNDATIONONE is a registered trademark of Foundation Medicine, Inc. All other product names and trademarks are the property of their respective owners. Bring our expertise in-house at sequencing.roche.com/aveniocgpkit or contact...