cobas® c 111 analyzer Small box. Big performance.

cobas® c 111 as part of Roche’s Core Lab clinical chemistry portfolio The cobas® c 111 analyzer is the smallest member of Roche’s cobas® Core Lab CC platform family, with a throughput of up to 85 t/h. Automation & Connectivity cobas® c 503** Up to 1000 t/h 4 cobas® c 303* Up to 450 t/h 3 cobas® c 311 Up to 300 t/h 2 cobas® c 111 Up to 85 t/h 1 S–M Maximum Throughput CC Photometric Testing CC: Clinical Chemistry; t/h: tests per hour. * cobas® pure integrated solutions ** cobas® pro integrated solut

cobas® c HI analyzer An instrument designed to fit in many ways Routine Perfectly suited as a main analyzer for: • Small labs • Small hospitals & clinics • Satellite labs of larger networks Serves well as a backup analyzer for larger cobas® clinical chemistry analyzers Used as a dedicated analyzer for: • STAT samples in emergency and intensive care departments by trained lab professionals Special testing such as only for HbAlc

Why customers choose the cobas® c 111 analyzer? Small box. Big performance Excellent performance Roche lab quality test results with high accuracy and precision5-7 Highly reliable system Globally trusted technology Robust system design, requiring a repair visit only once per 1.5 years5* ~6700 installed active analyzers across 125 countries5 Standard Roche results Aligned results across Roche cobas® platform using same reagent chemistry6 Compact and convenient Over 40 different tests on only 0.3m², easy to use touch screen & software, low water consumption (<3l / day) High Roche service level...

Smart features make the cobas® c 111 analyzer a great solution8Good fit for labs processing up to 85 tests per hour Exchangeable disks for flexible reagent handling • Preparation of up to 8 different reagent disks adaptable to individual panel testing • Each reagent disk can hold up to 27 bottles which allows for 13 different tests in one reagent disk • Prepared reagent disks can be stored in a fridge until needed and with one disk on board* • Independent and flexible water supply with 3 litre water and waste containers • Guiding software wizard for daily start-up and maintenance procedure •...

High level performance on a small footprint8 Dynamic transfer head • Multifunctional and lean design significantly reduces complexity by performing three functions in one: 1. Sample pipetting 2. Reagent pipetting 3. Mixing of sample and reagent • Sample probe is washed between steps to prevent carry-over • Samples can be loaded and unloaded continuously into eight positions • STAT processing prioritizes emergency samples for next pipetting cycle • Onboard sample and calibrator dilution User interface • User-friendly and easy to use user interface • Online help function as a quick reference guide...

Comparable with larger Roche clinical chemistry analyzers, using common reagent chemistry HDL-Cholesterol Gen.4 method comparison Diluted sample Native samples HDLC 4 cobas® c 111 analyzer [mmol/L] Spiked sample 3 P/B Regression Y = 0.998 * X -0.0165 md(95) = 0.0272 n = 55, r = 0.999 t = 0.975 HDLC 4 cobas® c 503 module [mmol/L] Proven consistency of results9 Same reagents used for cobas® c packs and cobas® c 111 reagent bottles, delivering comparable results across the cobas® platform Same calibrators and controls available for all cobas® clinical chemistry analyz

Amylase – pancreatic Alkaline phosphatase (IFCC) Amylase – total ALT/GPT with and without Pyp AST/GOT with and without Pyp Bilirubin – direct Bilirubin – total Gamma glutamyl transferase Infectious Diseases Lactate dehydrogenase Albumin immunologic Creatinine (enzymatic) Total protein Creatinine (Jaffé) Lactate dehydrogenase

cobas® c 111 analyzer A continuous random- access analyzer intended for the in vitro determination of clinical chemistry parameters Test throughput Sample types Serum, plasma, urine, whole blood (HbA1c) Sample input Continuous loading of primary and secondary tubes into 8 sample positions Priority STAT sampling Time to first result Sample container types Primary tubes Sample cup Micro cup Cup on tube False bottom tube Primary tubes 500 μL Sample cup 75 μL Micro cup 50 μL Sample volume Sample barcode types Code 128, Codabar 2 of 7, Interleaved 2 of 5, Code 3 of 9, Codabar, EAN, UPC (A, E) QR,...

1. Roche Diagnostics International Ltd. cobas® c 111 analyzer User Guide Version 4.5 Software Version 4.3. 2. Roche Diagnostics International Ltd. cobas® c 311 analyzer Operator's Manual Version 3.2 Software Version 01-13. 3. Roche Diagnostics International Ltd. cobas® pure integrated solutions User Guide Version 2.2 Software Version 01-04. 4. Roche Diagnostics International Ltd. cobas® pro integrated solutions User Guide Version 4.0 Software Version 03-01. 6. Roche (2023). Calculated method comparison of cobas® c 501 vs. cobas® c 111. Data on file. 7. Roche Diagnostics International Ltd. Method...