MagNA Pure 96 system

MagNA Pure 96 system
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MagNA Pure 96 system

Product catalog summary
Overview
The MagNA Pure 96 system is a high-throughput instrument designed for automated nucleic acid purification, capable of processing 96 samples in less than 30 minutes. It enhances laboratory productivity with pre-programmed protocols and proven magnetic glass particle technologies, suitable for a wide range of genomic applications.
Key Features
  • Automated purification of 96 samples in under 30 minutes.
  • Intuitive graphical user interface for ease of operation.
  • Prefilled, barcoded reagent kits for error reduction and process documentation.
  • Proven performance with over 20 years of magnetic bead technology.
  • Contamination prevention features including UV lamp and CO-RE Tip technology.
Software and Kits
  • MagNA Pure 96 software offers error detection and corrective action guidance.
  • Three reagent kits available for different starting materials and targets, including DNA, RNA, and viral nucleic acids.
Performance and Efficiency
  • High-quality extracts with consistent yields.
  • Fully automated workflow minimizes handling errors.
  • Data management with audit trail and LIMS connectivity.
  • Supports a broad range of sample types and pre-programmed protocols.
Applications and Scalability
  • Suitable for various sample types including whole blood, plasma, serum, and more.
  • Scalable to meet laboratory growth and testing fluctuations.
  • New protocols for faster processing and enhanced small fragment isolation.
Customer Feedback
  • Positive testimonials highlight increased productivity, reduced turnaround times, and high-quality, reproducible results.
Technical Specifications
  • Benchtop standalone instrument with a capacity of 1 to 96 reactions per run.
  • Sample input volume ranges from 50 µL to 4 mL, with elution volumes of 50 to 200 µL.
  • Compliant with IVD Regulation (EU) 2017/746 for in vitro diagnostic use.
Specifications
  • FLOW PCR Setup System: Automates PCR setup, eliminating manual pipetting, and supports high-speed multi-dispensing into 96- or 384-well plates. It offers retest and reflex options from processed eluates.
  • MagNA Pure 96 System: Capable of processing up to 96 samples in 30 minutes, it extracts DNA, RNA, and total nucleic acids using a single protocol. It can connect up to three systems for expanded throughput.
  • FLOW Primary Sample Handling Instrument: Accepts various sample types and tubes, pipettes samples into processing cartridges, and includes clot detection and closed housing for contamination control.
  • LightCycler 480 Instrument: Performs 40 cycles in under an hour, supports various qPCR chemistries, and can connect up to five instruments for increased throughput.
  • PRO System: Offers 7-channel multiplexing, precise temperature regulation, and a large touchscreen interface, delivering up to 2,688 tests per hour.
Procedures and Standards All systems are produced under GMP conditions, ensuring high reliability and performance. The document emphasizes automation, reduced hands-on time, and contamination control through modular setups and UV-light equipped housings.
Recommendations The document suggests using these systems for general laboratory use and life science research, with specific kits and consumables available for in vitro diagnostic purposes.
Ordering Information Detailed catalog numbers and contents are provided for instruments, reagent kits, lysis buffers, and consumables, facilitating easy procurement.
Conclusion The document underscores the efficiency, flexibility, and scalability of the MagNA Pure and LightCycler systems, making them suitable for various laboratory applications.
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Catalog excerpts

MagNA Pure 96 system-1

MagNA Pure 96 system Start here. Go anywhere.

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MagNA Pure 96 system-2

The MagNA Pure 96 system is a high-throughput instrument for automated nucleic acid purification. Typical run duration is one hour for 96 standard volume samples. Experience high-throughput automation combined with high performance while increasing your laboratory productivity to meet your changing needs. • Enable purification of 96 samples in less than 30 minutes • Simplify your workflow with pre-programmed protocols tailored to different sample requirements • Utilize proven magnetic glass particle technologies • Rely on eluates suitable for a broad range of genomic applications • Magnify your...

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MagNA Pure 96 system-3

MagNA Pure 96 Kits are prefilled and ready-to-use reagent trays that can be easily loaded into racks, ensuring user ease and safety. These kits, as well as the consumables, are barcoded and read by the MagNA Pure onboard scanner for inventory check, loading errors, and process documentation. ** FFPET - formalin-fixed paraffin-embedded tissue + For life science research only. Not for use in diagnostic procedures. MagNA Pure 96 softwareIntuitive user interface The intuitive graphical user interface provides all instructions to operate the system, such as sample loading to run start. The software...

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MagNA Pure 96 system-4

Proven performance• Over 20 years of successful magnetic bead technology • High-quality extract with reproducible and consistent yields • Dedicated, experienced support and service teams • Minimal consumables • On-board barcode scanning for inventory • Streamlined kit offering that purifies a variety of nucleic acids • Intuitive graphical interface • Drop catcher • CO-RE Tip technology with stable lock-and-key fit which eliminates the risk of cross-contamination

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MagNA Pure 96 system-5

Accelerated results • 96 samples in less than 30 minutes* • Parallel handling of all samples with 2 robotic arms • Set-up in less than 5 minutes • Software with audit trail and user management • LIMS host connectivity • Broad range of supported samples • Pre-programmed protocols, including “Pathogen Universal” that extracts DNA and RNA from 10 common samples • Eluate used for a variety of downstream applications • Fully automated workflow • Error detection with corrective action guidance • Deck and volume surveillance • Barcoding of kits and consumables for more details check the download protocols...

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MagNA Pure 96 system-6

Benefit from consistency of automation Linearity of RT-PCR of total RNA HeLa Experiment details1 Kit: MagNA Pure 96 Cellular RNA Large Volume Kit Sample: HeLa and K-562 cells LightCycler® experiment: Reverse Transcriptase PCR for the transcript of the Cyc A gene (one-step PCR). Convenience and flexibility in one Experiment details1 Extraction from a variety of samples and targets using one protocol Parvo B19 EDTA Plasma Citrate Plasma Nasal swab Protocols: DNA Blood SV (Plasma, Serum) Pathogen Universal 200 (Stool, swab, urine) Sample: Various types spiked with Parvo B19 (DNA virus), Hepatitis...

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MagNA Pure 96 system-7

Increased ability to meet growth and testing fluctuations Fast protocols in less than 30 minutes – External lysis of RNA virus The new Fast Viral NA SV protocol shows similar performance as the existing Pathogen Universal 200 protocol from RNA virus from swabs. Experiment details1 Sample Input NA Swabs SARS-CoV-2 ERIS (EG.5.1.3) variant Fast Viral NA ext lys SV and Viral NA Plasma ext lys SV MagNA Pure 96 DNA and Viral NA SV Kit MagNA Pure Buffer MagNA Pure External Lysis Buffer Sample Treatment As described in IFU. 200 µl of sample material is premixed with 250 µl of external lysis buffer Elution...

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MagNA Pure 96 system-8

Increased ability to meet growth and testing fluctuations Fast protocols in less than 30 minutes – Internal lysis of RNA virus The Fast Viral NA SV protocol shows similar performance as the existing Pathogen Universal 200 protocol from RNA virus from swabs. Fast Viral NA SV and Pathogen Universal 200 MagNA Pure 96 DNA and Viral NA SV Kit Sample Treatment No. 200 µl swab in viral transport medium Elution volume Analytical methods qPCR for selected targets (Roche LightCycler® PRO Real-Time PCR Instrument) VirSNiP SARS-CoV-2 Spike Q52HTIB together with LightCycler Multiplex RNA Virus Master Each...

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MagNA Pure 96 system-9

“In our laboratory, we use MagNA Pure 96 instruments to purify nucleic acids from all types of samples for PCR pathogen detection and genetic analysis. We appreciate the high quality, reproducibility and reliability of the nucleic acid extraction combined with a short hands-on time. However, one drawback was that the purification process took about an hour. As speed is a critical issue in molecular diagnostics, we were happy to participate in the evaluation of the new fast protocols. In our hands, the differences from the original protocol were negligible, while the turnaround time was about...

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MagNA Pure 96 system-10

High throughput and scalability Prevention of contamination Three runs (each with 48 positive spiked plasma samples and 48 negative samples arranged in a checkerboard pattern) were extracted on the MagNA Pure 96 system and then analyzed on the LightCycler® 480 Instrument*.1 No cross-contamination was found.1 Kit: MagNA Pure 96 DNA and Viral NA LV Kit Protocol: Large Volume protocol (500 µL) Sample: EDTA plasma Pathogen: Parvo B19 at 5 x 10^7 copies/mL (=10^6 above detection limit) 10 Highly reproducible results qPCR results from the MagNA Pure 96 system extracted samples are highly reproducible...

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MagNA Pure 96 system-11

Growing with your needs Scale with ease Go anywhere with scalability for your lab’s growth. The MagNA Pure 96 system is significantly faster than two other competitor brands. When considering daily, monthly, and yearly capacity needs, the MagNA Pure 96 system provides increased ability to meet growth and testing fluctuations.1,2 Buccal swab Roche Minutes Whole blood Testing Capacity (In Samples) Beyond extraction Unlock more of the answers you need with the new 4 mL volume protocol for circulating cell-free nucleic acids (cfNA) on the MagNA Pure 96 system by preferentially isolating smaller size...

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