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Maximize Consistency

Product catalog summary

Introduction
KAPA HyperPure Beads are part of Roche's Sample Prep Solutions, designed to enhance the next-generation sequencing (NGS) workflow by providing high-performance library preparation reagents. These beads are crucial for reaction purification and size selection in DNA library construction workflows.

Key Benefits

Best-in-class nucleic acid recovery for KAPA NGS DNA workflows, offering tunable and consistent size selection.
Improved bead wash efficiency enhances library diversity and reduces sequencing costs.
Fast and efficient reaction cleanups remove unwanted components such as adapters, primers, nucleotides, salts, and enzymes.
Ready-to-use and compatible with automation systems.

Performance and Comparison

KAPA HyperPure Beads provide superior DNA recovery compared to a leading competitor (Supplier A), across various input amounts, sizes, and qualities.
They facilitate the manipulation of DNA samples, such as buffer exchange to remove salts before enzymatic fragmentation.

Size Selection Capabilities

Enable reproducible size selection of nucleic acids, crucial for capturing fragmented input DNA and amplified libraries in NGS workflows.
Allow researchers to consistently select desired fragment sizes.

Figures and Data

Figure 1 demonstrates superior recovery performance of KAPA HyperPure Beads compared to Supplier A in DNA workflows, including recovery of unfragmented and degraded human genomic DNA.
Figure 2 illustrates the tunable size selection of double-stranded DNA using different bead-to-sample ratios, analyzed with a Bioanalyzer.

Ordering Information
Available in various kit sizes ranging from 5 mL to 450 mL, with specific catalog numbers for ordering.

Usage and Restrictions
KAPA and LightCycler® products are for research use only and not for diagnostic procedures. KAPA and KAPA HYPERPREP are trademarks of Roche.

Catalog excerpts

MaximizeConsistencyKAPA HyperPure Beads: Attract what matters. In the NGS workflow continuum, sample prep holds the key to unlocking the potential of every sample. Roche Sample Prep Solutions provide a dynamic, reliable, and focused portfolio of high-performance, high-quality library preparation reagents that enable you to process more samples successfully, obtain more information from every sample, and optimize sequencing resources. This includes KAPA HyperPure Beads that offer a tunable and highly consistent solution for reaction purification and size selection in next-generation sequencing (NGS) DNA library construction workflows. • KAPA HyperPure Beads offer best-in-class nucleic acid recovery for many KAPA NGS DNA workflows, providing tunable and consistent size selection • Improved bead wash efficiency maximizes library diversity and reduces sequencing costs • Fast, efficient reaction cleanups remove adapters, adapter-dimers, primers, primer-dimers, nucleotides, salts, and enzymes • KAPA HyperPure Beads are ready-to-use and automation-friendly

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U UUAI UUAI L.UAI uuni OU/AI L.UMI L-U/AI UU/AI L.UMI UUAI lAani UU/AI L.U/AI L.U/AI OU/AI OUMI L.UMI lAani UU/AI L.UMI L-U/AI UU/AI oU • KAPA HyperPure Beads achieve comparable or better DNA recovery than the market leader (Supplier A) across a broad spectrum of input amounts, sizes, and quality • Improved general manipulation of DNA samples, e.g., buffer exchange to remove EDTA or other salts prior to enzymatic fragmentation and sample concentration Recovery of Human gDNA Recovery of Human FFPE gDNA ■ KAPA HyperPure Beads Input amount (ng) Figure 1. KAPA HyperPure Beads provide superior recovery...

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