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Roche Personalised Healthcare Small differences, big effects - 23 Pages

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Roche Personalised Healthcare Small differences, big effects

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Roche Personalised Healthcare Small differences, big effects

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Dear reader, Dear reader, Dear reader, Dear reader, It gives us great pleasure to present you with a personalised edition of this brochure. It gives us great pleasure to present you with a personalised edition of this brochure. It gives us great pleasure to present you with a personalised edition of this brochure. It gives us very great pleasure to present you with a personalised edition of this brochure. The copy you are holding is from the YELLOW 1 group. What does that mean? The copy you are holding is from the YELLOW 2 group. What does that mean? The copy you are holding is from the...

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Personalised Healthcare means fitting treatments to different groups of patients. Our vision of Personalised Healthcare is becoming reality. The future of medicine lies in customisation of this kind. Roche Personalised Healthcare

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Personalised Healthcare – The core of our Group strategy Back in 2006, Roche made Personalised Healthcare central to its Group strategy. This was the first stage in its commitment to transforming the vision into reality now. Severin Schwan, CEO Roche ‘Many heart-to-heart talks with patients and doctors have brought it home to me just how immense the need for better or even entirely new diagnoses and medicines actually is. Our efforts are geared to giving people with dangerous diseases genuine prospects for a better and a longer life. My most important job is to provide our researchers with...

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Standard therapy means same syndrome, same therapy. Patients with same syndrome One-size-fits-all approach Personalised Healthcare means the right therapy for the right group of patients at the right time. Group of patients with the same syndrome Targeted therapy Roche Personalised Healthcare

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Why Personalised Healthcare is so important ‘It is more important to know what sort of person has a disease than what sort of dis­ ase a person has.’ This verdict on the importance of gearing one’s healing efforts e to the individual patient rather than the disease was uttered by Hippocrates, the most famous physician of antiquity. The modern term for this approach is ‘Personalised Healthcare’. Some 2,400 years after Hippocrates, it is driving a genuine revolution based on the scientific realisation that individuals are different – and so are diseases. Personalised Healthcare aims to...

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Personalised Healthcare gets down to the molecular roots of disease What makes individuals so similar and at the same time so unique? And what exactly goes on in the body when people are healthy or sick? These questions have always intrigued scientists, but it took molecular biology to come up with the really important answers. Major milestones were the discovery of the double helix (the structure of the 'life molecule' human genome at the beginning of the new millennium. Today, findings from new branches of research like genomics or proteomics enable researchers to refine their...

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Once the molecular causes of a disease have been identified, we have a chance of developing targeted diagnostic methods and medicines adapted to the genetic constitution of these degenerate cells. Perhaps in future, physicians will no longer speak of skin or lung cancer. Instead the focus will be on the respective molecular blueprint and tumours with specific mutations that can be diagnosed with gene-based methods and treated with specifically targeted medicines, regardless of the part of the body that has been affected. Personalised Healthcare is the strategy of the future for cancer but...

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Stomach cancer What is stomach cancer? Stomach cancer can develop in the tissue of the stomach itself or in the junction between the oesophagus and the stomach. In its early stages, the cancer is restricted to these regions. If the disease spreads to the rest of the body in the form of metastases (secondary tumours), it is referred to as advanced or metastatic stomach cancer. How common is stomach cancer? Stomach cancer is the fourth most common kind of cancer worldwide and the second cause of all cancer deaths. It is diagnosed in about one million persons every year. The disease is more...

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Breast cancer How common is breast cancer? Every year, about 1.4 million new cases of breast cancer are diagnosed worldwide. Advances in the treatment of breast cancer are continuously being made but 450,000 women still die of this disease each year. How is HER2-positive breast cancer diagnosed? On average, one in five breast cancer tumours displays an overproduction of HER2 receptors on the tumour cells. Targeted treatment homes in on these receptors. At Roche, experts from both divisions work closely together to ensure the high quality of HER2 tissue tests and to reliably identify those...

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Non-small cell lung cancer How common is non-small cell lung cancer and what molecular features does it display? Non-small cell lung cancer is the most common tumourconditioned killer worldwide. Despite its apparently uniform classification, this type of tumour varies with the genetic defects underlying it. One example is a mutation of the gene responsible for the formation of the epidermal growth factor receptor. The mutation is found in approximately 30 percent of all patients from Asia, and in about ten percent of those from western countries. In another subgroup of patients suffering...

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Skin cancer What is metastatic melanoma? Metastatic melanoma is the deadliest and most aggressive form of skin cancer. A metastatic melanoma develops when the ‘melanocytes’ – the pigment cells in the skin – proliferate in an uncontrolled way. If identified and treated early, melanomas respond well to treatment. But once metastases (secondary tumours) have formed and spread through the body, the chances of recovery are slight. Metastatic melanoma is the most aggressive kind of skin cancer Where Personalised Healthcare comes in Skin cancer therapy is the latest example of the approach...

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