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Fluorescence fiber photometry system

Fluorescence fiber photometry system

Fluorescence fiber photometry system

Product catalog summary
Introduction
The document introduces the Fluorescence Lifetime Fiber Photometry System, a tool designed to monitor fluorescence lifetime signals in freely moving animals. This system is used to analyze neural circuits, study chronic disease models, and conduct quantitative analysis of neurotransmitters.

Application Scenarios
  • Circuit Analysis: Used to study neural mechanisms related to learning, memory encoding, and social behavior.
  • Pathological Research: Provides stable signal monitoring for chronic diseases like anxiety disorders and Alzheimer's disease.
  • Quantitative Analysis: Enables the study of neurotransmitters such as dopamine and acetylcholine.
  • Molecular Biochemical Research: Investigates protein conformational changes using fluorescence lifetime properties.

Product Introduction
The system connects to animals via optical fiber to detect changes in the lifetime of fluorescent proteins. It uses a picosecond pulsed laser to excite proteins and collect signals, allowing for the detection of neural activity and quantitative analysis of neurotransmitter concentrations.

Product Advantages
  • Strong Anti-Interference Ability: Unaffected by animal movement, enhancing signal-to-noise ratio and stability.
  • Cross-Sample Comparison: Allows direct data comparison across different animals without interference from individual differences.
  • Long-Term Stability: Less affected by photobleaching, suitable for chronic disease models and long-term studies.

Technical Parameters
  • Excitation Wavelengths: 488 nm, 515 nm, 560 nm, 640 nm, and 670 nm; custom wavelengths available.
  • Pulse Frequency: 1‒80 MHz adjustable.
  • Fluorescence Lifetime Detection Range: 1~10 ns.
  • Time Channel Width: ≤50 ps.
  • Sampling Rate: 1~50 Hz.
  • Digital Signal Interface: 8 digital I/O ports.

Contact Information
RWD Life Science Co., Ltd and RWD Life Science Inc. provide contact details for further inquiries.
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Catalog excerpts

Fluorescence fiber photometry system-1

Fluorescence Lifetime Photometry System Product Introduction The Fluorescence Lifetime Fiber Photometry System connects to animals via optical fiber, enabling the detection of changes in the lifetime of fluorescent proteins in the brains of freely moving animals. Fluorescence lifetime refers to the duration that a fluorescent protein molecule remains in the excited state after being activated by light. It is not affected by non-experimental factors such as protein expression levels, and can change when binding to target substances, thus featuring excellent data consistency and anti-interference ability. This product uses a picosecond pulsed laser to excite fluorescent proteins of specific wavelengths and collects fluorescence lifetime signals through optical fiber, thereby realizing the detection of neural activity in freely moving animals and the quantitative study of the concentration of target substances such as neurotransmitters. Application Scenarios Circuit Analysis: Dynamically monitor fluorescence lifetime signals to analyze neural circuits in animals with free behaviors (e.g., the neural mechanisms of learning and memory encoding and social behavior). Pathological Research: Achieve long-term stable signal monitoring for chronic disease models (e.g., anxiety disorder, Alzheimer's disease). Quantitative Analysis: Realize the quantitative study of substances such as neurotransmitters (e.g., dopamine, acetylcholine) based on the lifetime changes of fluorescent probes. Molecular Biochemical Research: Study the conformational changes of protein molecules by utilizing the characteristic properties of flu

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Fluorescence fiber photometry system-2

Product Advantages Strong Anti-Interference Ability Cross-Sample Comparison Unaffected by animal movement, significantly enhancing signal-to-noise ratio and stability. Long-Term Stability Unaffected by excitation light intensity and probe expression concentration, allowing direct comparison of data from different animals and avoiding interference from individual differences. Less affected by photobleaching, enabling the acquisition of high-quality and reliable data, which is suitable for chronic disease models and long-term tracking studies of behaviors. Product Principle laser pulse fluorescence photon...

 Open the catalog to page 2

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