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RWD Life Science
RWD Infusion imager RFLSI Ⅲ

RWD Infusion imager RFLSI Ⅲ

Product catalog summary

Overview: The RFLSI Ⅲ is a Laser Speckle Imaging System designed for pre-clinical research on vascular studies. It utilizes Laser Speckle Contrast Imaging (LSCI) technology to visualize tissue blood perfusion with high temporal and spatial resolution without the need for contact, dyes, or tracers.

Specifications:

Model: RFLSI Ⅲ
Monitoring Band: 0-5000 PU
Image Acquisition Speed: Up to 120 FPS
Image Size: Less than 90mm x 90mm
Camera: Dual CMOS (Color), 5.0 million pixels (2048 x 2048)
Zoom Range: 12× optical zoom with auto-focus
Monitoring Laser: 785 nm, 110mW
Indicator Laser: 660 nm
Region of Interest (ROI): Square, circle, polygon

Applications: The system is applicable in various research areas including cerebral blood flow monitoring, skin blood flow monitoring, organ blood flow monitoring, and studies on neovascularization/angiogenesis, cortical spreading depolarization, and stroke models.

Technical Insights: The speckle contrast analysis is based on the dynamic changes in the speckle pattern caused by motion in the sample. The system records these changes with a camera, and the level of blurring in the image is quantified by the speckle contrast.

Advantages:

Quantized Data: Provides in-vivo data and quality control standards for ischemia models.
Real-time Data: Allows for real-time monitoring of reperfusion data during ischemia models.
Visual Data: Offers 4K imaging capabilities for detailed visualization of blood vessels.

Case Studies:

Studies on diabetic peripheral neuropathy in mice using DW14006 as a direct AMPK activator.
Research on platelet activation involving the 14-3-3ζ-c-Src-integrin-β3 complex.
Investigation of meningeal lymphatic vessels in clearing erythrocytes from subarachnoid hemorrhage.
Analysis of arterial supercharging benefits on flap survival, showing significant differences in vascular dilation and perfusion values.

Catalog excerpts

Applications Cerebral Blood Flow Monitoring Cortical Spreading Depolarization (CSD) Neovascularization/ Angiogenesis Stroke Model (MCAO) Skin Blood Flow Monitoring Organ blood ﬂow monitoring Chicken Chorioallantoic Membrane (CAM) Assay Hind Limb Ischemia (HLI) Laser Speckle Imaging System F o r P r e - C l i n i c a l R e s e a r c h a b o u t V a s c u l a r. Parameter Model Image acquisition speed Image size Camera Zoom range Monitor camera Image camera Monitoring Laser Laser power Indicator laser Region of interest(ROI) ROI shape Vascular diameter Data Dual CMOS(Color) On-line & Oﬀ-line analysis Square, circle, polygon On-line & Oﬀ-line analysis Imagine, Video Blood Perfusion RWD Life Science Co.,Ltd Add: 6540 Lusk Blvd, Suite C161 San Diego, CA 92121 U.S.A Te l : (8 5 8 ) 9 0 0 - 5 8 7 9 E-ma il : s e r v i ce@r wdl s .com RWD RFLSI Ⅲ Laser Speckle Imaging System- Flyer-V1.0-2021-02-25-EN

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Laser Speckle imaging system (RFLSI Ⅲ) Laser Speckle Imaging System (RFLSI Ⅲ) is a blood perfusion imager based on Laser Speckle Contrast Imaging (LSCI) technology. LSCI provides a better means to study the microcirculation that were not possible in the past. It allows visualization of tissue blood perfusion and imaging with high time and spatial resolution. There is no inﬂuence on the perfusion, as no contact to the tissue is needed, nor dyes or tracer elements. Speckle ﬂow techniques are based on the changes over time of the dynamic speckle pattern generated by motion in the sample. In these...

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