When a life is on the line, but IV access isn’t an option, the NIO™ Family of Intraosseous Devices answers the call by delivering life-saving drugs, fluid or blood directly into the marrow of a bone. Oftentimes, IV access is not available or cannot be obtained quickly, putting patients’ lives at risk when seconds count. NIO intraosseous devices provide a non-collapsible entry point into the systemic venous system, making this ideal for use in patients with limited or no vascular access, or when the patient may be at risk of increased morbidity or mortality if access is not obtained. 1 In fact, according to 2020 American Heart Association Guidelines for CPR and ECC, “Although IV access is preferred, for situations in which IV access is difficult, IO access is a reasonable option.” 2 Select the NIO device that’s just right for your patient — whether an adult, child or infant, and experience the NIO difference, with this easy to use, sterile, singleuse, all in one intraosseous device. Additionally, the NIO+ A™ was designed with a reinforced core and packaging that resists elevated thermal temperatures in harsh, challenging environments, so life-saving intraosseous access is never out of reach. 1. The Role of the Registered Nurse in the use of Intraosseous Vascular Access Devices, April 17, 2020, Position Statement, The art and Science of Infusion Nursing 2. 2020 AHA Guidelines Update for CPR and ECC READYTOUSE: No batteries, assembly, or external power source are required. ALLINONE SOLUTION: Everything needed to achieve IO access, including a securement dressing. No additional parts or accessories required. SAFE: Unexposed needle decreases the risk of accidental needle injury; dual safety mechanisms to prevent unintentional activation. STERILE & SINGLEUSE: Reduces risk of crosscontamination. LONG SHELF LIFE : 5-year shelf-life. visit safeguardmedical.com call (US) +1 (855) 428-6074 / (Int’l) +44 (0) 1568 613942 email (US) [email protected] / (Int’l) [email protected] Devices included in this document may not be cleared or licensed for use or sale in your individual country. Please contact your local distributor for information regarding availability of these products. SAFE, RAPID, AND READY

COLOR-CODED TRAUMA SYSTEM CIRCULATION TESTIMONIALS FROM THE FIELD "I administered the first [NIO Adult™] and watched the second be administered. From time of package open to first [medication] administration was around 6 seconds. That's awesome!" - Firsthand user "...Really impressed with [the] NIO™. They like that it's quick, easy, and accurate. They also like that it is a single-use, sterile device—no searching around for different-sized needles and hoping a battery is charged. Overall, the feedback is very positive."- Third-Party Sales Rep "The initial reason for looking into the NIO™ was...