Bioreactor for protein production

miniPERM® Bioreactor for protein production • High cell densities • High product concentration • Easy handling • Multiple harvesting • Range of cell culture volumes Applications • Hybridoma cells • Transfected cells • Biomass production • Virus-producing cells • Entomological cells • Plant cells miniPERM® is an easy-to-handle bioreactor for the cultivation of cells in high densities and simultaneous production of cell products, e.g. monoclonal antibodies. Depending on the cell line, cell densities of more than 107 cells/ml and product concentrations of several mg/ml can be obtained. Universal...

Function The miniPERM® bioreactor is a membrane-based twocompartment system. Nutrient module A dialysis membrane subdivides the culturing chamber of the miniPERM® bioreactor into a production module (optionally 5, 35 or 50 ml cell culture volume) and nutrient module (400 ml medium volume). Production module Glucose Lactate Cell product + NH4 CO2 Zelle Simultaneously, the metabolites released from the cells diffuse through the dialysis membrane from the production module into the nutrient module to be diluted or neutralized in the medium. The outer side of the production module consists of a thin...

Bioreactor and accessories miniPERM® bioreactors are available in the following options: • miniPERM® sterile: Combined production and nutrient module, sterile, for single use only • miniPERM® reusable: The nutrient module is autoclavable and designed for multiple use. The production module is available as a sterile product for single use only. • miniPERM® accessories The following accessories are available for easy handling of the miniPERM® bioreactor during cultivation: sterile single-use syringe (2 ml, 50 ml), sterile tubes, Luer needle, septum port, miniPERM® stand, antiFOAM® (defoaming agent),...