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4500 Series of Instruments

4500 Series of Instruments
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4500 Series of Instruments

Product catalog summary
Operational Precautions and Limitations
  • General Safety Information: Users must follow all safety precautions and comply with relevant EHS regulations to prevent injury or system damage.
  • Documentation Symbols and Conventions: Symbols like DANGER, WARNING, and CAUTION indicate hazard severity.
  • Regulatory Compliance: The system adheres to international standards, including EMC and safety regulations for various regions.
Principles of Operation
  • System Overview: Describes the system's hardware and operational theory.
Operating Instructions — Hardware
  • Start Up and Shut Down: Provides detailed procedures for system startup and shutdown, including specific components like the syringe pump and diverter valve.
Service and Maintenance Information
  • Maintenance Schedule: Recommends regular maintenance tasks for optimal performance, including cleaning and component inspection.
Mass Spectrometer Troubleshooting
  • Guidance on resolving common mass spectrometer issues.
Appendices
  • Calibration Ions and Solutions: Details calibration procedures.
  • Glossary of Symbols and Warnings: Defines symbols and warnings used in the document.
Contact and Support
  • Information on contacting SCIEX for support and training.
Operational Precautions and Limitations
  • Safety Standards: Compliance with IEC 61010-1 and IEC 61010-2-061 is required.
  • Electrical Precautions: Only qualified personnel should handle electrical installations.
  • Mains Supply: Ensure emergency disconnection is possible and use only supplied mains cables.
  • Protective Earth Conductor: Must be installed by a qualified electrician.
  • Chemical Precautions: Decontaminate the system if hazardous materials were used.
  • System Safe Fluids: Use only specified LC-MS-grade solvents and buffers.
  • Ventilation Precautions: Ensure proper venting of fumes.
  • Physical Precautions: Allow cooling time for hot surfaces and use mechanical lifting devices for heavy components.
  • Environmental Precautions: Avoid explosive environments and maintain stable ambient temperatures.
  • Electromagnetic Compatibility: Operate in a basic electromagnetic environment.
  • Electromagnetic Interference: Classified as Class A equipment, suitable for non-residential environments.
  • Decommissioning and Disposal: Follow local regulations for disposal of hazardous and electronic waste.
  • Qualified Personnel: Only SCIEX personnel should install and service the equipment.
  • Laboratory Conditions: Operate indoors with specified temperature and humidity ranges.
Safety and Handling Precautions
Emphasizes using SCIEX-recommended parts and professional moving services. Protective footwear is advised for handling heavy objects.
System Overview
Describes the 4500 series instruments for chemical analysis, including key components like the mass spectrometer and ion source.
Principles of Operation
Explains the mass spectrometer's function, including ion transmission and filtering processes.
Hardware Overview
Details the mass spectrometer's hardware, including connections and LED functions.
Operating Instructions
Provides startup instructions, including gas connections and component configurations.
Warnings and Cautions
Highlights potential hazards and the importance of following procedures.
System Shutdown and Venting Procedures
Outlines steps for safely shutting down and venting the system.
Mass Spectrometer Reset
Provides instructions for resetting the mass spectrometer.
Operating Instructions and Workflows
Describes tasks and references for different user roles.
Maintenance and Safety Guidelines
Emphasizes regular maintenance and safety warnings.
Cleaning Procedures
Details cleaning methods to avoid damage and maintain system integrity.
Service and Maintenance Information
  • Curtain Plate Removal and Cleaning: Instructions for cleaning and reinstallation.
  • Orifice Plate Cleaning: Cleaning instructions without removing the interface heater.
  • Source Exhaust Drain Bottle Maintenance: Regular inspection and maintenance instructions.
  • Roughing Pump Oil Level: Instructions for checking and maintaining oil levels.
Storage and Handling
  • Storage conditions and contact information for long-term storage assistance.
Troubleshooting
  • System Issues: Solutions for common issues like low gas flow and high vacuum pressure.
  • Sensitivity Issues: Recommendations for cleaning and optimization.
  • Background Noise: Cleaning and conditioning advice for high noise levels.
Calibration and Tuning
  • Regular calibration and tuning recommendations.
Glossary of Symbols
  • Explanation of symbols indicating compliance, hazards, and operational instructions.
Overview: The document is a user guide for the 4500 Series of Instruments, providing safety information, symbol glossary, warnings, and contact details for support and training.
Glossary of Symbols: Lists symbols used in the document and their meanings.
Warnings: Emphasizes careful handling and servicing by qualified personnel only.
Customer Support and Training: Provides contact information for support and training.
Documentation Access: Instructions for accessing electronic and printed versions of the document.
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Catalog excerpts

4500 Series of Instruments-1

4500 Series of Instruments System User Guide

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4500 Series of Instruments-2

This document is provided to customers who have purchased SCIEX equipment to use in the operation of such SCIEX equipment. This document is copyright protected and any reproduction of this document or any part of this document is strictly prohibited, except as SCIEX may authorize in writing. Software that may be described in this document is furnished under a license agreement. It is against the law to copy, modify, or distribute the software on any medium, except as specifically allowed in the license agreement. Furthermore, the license agreement may prohibit the software from being disassembled,...

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4500 Series of Instruments-3

System User Guide RUO-IDV-05-13347-A

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4500 Series of Instruments-4

System User Guide RUO-IDV-05-13347-A

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4500 Series of Instruments-5

Operational Precautions and Limitations Note: Before operating the system, carefully read all of the sections of this guide. This section contains general safety-related information and provides regulatory compliance information. It also describes potential hazards and associated warnings for the system and the precautions that should be taken to minimize the hazards. In addition to this section, for information about the symbols and conventions used in the laboratory environment, on the system, and in this documentation, refer to the section: Glossary of Symbols. For site requirements, including...

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4500 Series of Instruments-6

Operational Precautions and Limitations WARNING! Warning signifies an action that could cause personal injury if f * \ precautions are not followed. CAUTION: Caution signifies an operation that could cause damage to the system or corruption or loss of data if precautions are not followed. Note: Note emphasizes significant information in a procedure or description. Tip! Tip provides useful information that helps apply the techniques and procedures in the text for a specific need and provides shortcuts, but is not essential to the completion of a procedure. This system complies with the regulations...

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4500 Series of Instruments-7

Operational Precautions and Limitations • Electromagnetic Compatibility (EMC): Electromagnetic Compatibility Directive 2014/30/EU as implemented in these standards: Refer to the section: Electromagnetic Compatibility. • Safety: Low Voltage Directives 2014/35/EU as implemented in these standards: • Waste Electrical and Electronic Equipment (WEEE): Waste Electrical and Electronic Equipment Directive 2012/96/EEC, as implemented in EN 40519. Refer to the section: Waste Electrical and Electronic Equipment. • Packaging and Packaging Waste (PPW): Packaging and Packaging Waste Directive 94/62/EC • RoHS...

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4500 Series of Instruments-8

Operational Precautions and Limitations Electrical Precautions WARNING! Electrical Shock Hazard. Do not remove the covers. Removing the covers might cause injury or malfunctioning of the system. The covers need not be removed for routine maintenance, inspection, or adjustment. Contact a SCIEX Field Service Employee (FSE) for repairs that require the covers to be removed. • Follow required electrical safe work practices. • Use cable management practices to control electrical cables. This will decrease the chance of a tripping hazard. For information about system electrical specifications, refer...

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4500 Series of Instruments-9

Operational Precautions and Limitations Protective Earth Conductor The mains supply must include a correctly installed protective earth conductor. The protective earth conductor must be installed or examined by a qualified electrician before the system is connected. WARNING! Electrical Shock Hazard. Do not intentionally interrupt the protective earth conductor. Any interruption of the protective earth conductor creates an electrical shock hazard. WARNING! Electrical Shock Hazard. Make sure that a protective earth conductor (grounding cable) is connected between the sample loop and an appropriate...

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4500 Series of Instruments-10

Operational Precautions and Limitations • Always wear assigned personal protective equipment, including powder-free gloves, safety glasses, and a laboratory coat. Note: Nitrile or neoprene gloves are recommended. • Work in a well-ventilated area or fume hood. • Avoid ignition sources when working with flammable materials, such as isopropanol, methanol, and other flammable solvents. • Take care in the use and disposal of any chemicals. There is potential risk of personal injury if proper procedures for handling and disposal of chemicals are not followed. • Avoid skin contact with chemicals during...

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4500 Series of Instruments-11

Operational Precautions and Limitations • Ammonium acetate; less than 100 mM • Ammonium formate; less than 100 mM • Formic acid; less than 1% • Acetic acid; less than 1% • Trifluoroacetic acid (TFA); less than 1% • Heptafluorobutyric acid (HFBA); less than 1% • Ammonia/ammonium hydroxide; less than 1% The venting of fumes and disposal of waste must comply with all of the federal, state, provincial, and local health and safety regulations. It is the responsibility of the customer to make sure that the air quality is maintained in compliance with local health and safety regulations. The source...

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4500 Series of Instruments-12

Operational Precautions and Limitations WARNING! Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard. Do not use the ion source without knowledge of and training in the proper use, containment, and evacuation of toxic or injurious materials used with the ion source. WARNING! Puncture Hazard, Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard. Discontinue use of the ion source if the ion source window is cracked or broken, and then contact a SCIEX Field Service Employee (FSE). Any toxic or injurious materials introduced in the equipment will be present in the source exhaust...

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4500 Series of Instruments-13

Operational Precautions and Limitations WARNING! Biohazard. For biohazardous material use, always comply with local regulations for hazard assessment, control, and handling. This system or any part is not intended to act as a biological containment. WARNING! Environmental Hazard. Follow established procedures for disposal of biohazardous, toxic, radioactive, and electronic waste. The customer is responsible for disposal of hazardous substances, including chemicals, waste oils, and electrical components, in accordance with local laws and regulations. CAUTION: Potential Mass Shift. Maintain a stable...

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