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Biomarker and Omics Solutions for Metabolomics - 7 Pages

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Biomarker and Omics Solutions for Metabolomics

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Biomarker and Omics Solutions FOR METABOLOMICS

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The metabolome consists of the entirety of small molecules consumed or created in the metabolic processes that sustain life. Metabolomics is the systematic study of Intelligent workflows combined with powerful technology Our industry leading hardware and application-focused workflows deliver answers to your most pressing metabolomics questions. these processes and the molecules involved. Discover and Screen and proteomics, metabolomics can provide insights into cellular processes and the health and inner-workings of biological systems. Complimentary to genomics, transcriptomics, discover...

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A pathway to success Metabolomics research occurs along a continuous pipeline. Typically, it begins with a small number of samples to test hypotheses and identify and characterize key metabolites. These metabolites are then verified and validated in greater numbers of samples to account for biological variation. Finally, assays are developed for routine quantitation of the metabolites. Metabolomics research pipeline SCREEN AND DISCOVER Solutions for metabolomics research L C H A R D WA R E COMPELLING HARDWARE The TripleTOF™ 5600 system and QTRAP® 5500 system Advion TriVersa NanoMate ®...

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Three processing strategies. With the TripleTOF™ 5600 system and one sample injection you can acquire one data file using our profile workflow, and process that data in three unique and very powerful processing strategies for qualitative and quantitative information: 1 ] Non-targeted metabolomics - Global profiling 2] Targeted metabolomics - Pathway screening 1 ] Non-targeted metabolomics - Global profiling Global metabolite profiling is used to identify interesting metabolites and potential biomarkers in a non-targeted fashion. For globa metabolite profiling LC/MS data was acquired across...

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2 ] Targeted pathway screening Targeted pathway screening is a powerful workflow for For in-depth lipid analysis, LipidView™ Software enables differential highlighting up/down regulation of metabolites in biochemical profiling of specific lipid species by identifying and confirming pathways such as glycolysis and TCA cycle. Known biochemical lipids with it’s built-in library feature. Data files are opened in the pathways can be screened by analyzing data with XIC Manager within PeakView™ Software. DNA methylation other methylations A pre-defined target list is uploaded to the XIC Manager...

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Targeted quantitation Once metabolites of interest are found, the next step is to monitor and quantitate them across many samples and experiments. The workhorse for quantitative data processing is MultiQuant™ Software. No other software program delivers the algorithmic power to definitively quantitate at the lowest levels. Using an MRM workflow on a QTRAP® System, metabolites of interest are monitored in a targeted fashion, but with the capacity to rigorously quantify 1000’s of metabolites from a single injection. Design your own method, or use a reagent kit and standards to monitor a set...

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You invest in our technology. We invest in your success. As the world leader in mass spectrometry, AB SCIEX creates solutions that are backed by the industry’s most extensive service and support organization. With a network of service professionals, experienced compliance specialists, and over 150 PhD application scientists worldwide, we are dedicated to supporting your technical needs and helping you get the most out of your AB SCIEX systems. AB SCIEX service professionals are recognized as the most highly qualified in the industry. They are certified on our instrument platforms through a...

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