AB SCIEX 4500 SERIES MASS SPECTROMETERS The new workhorse for LC/MS/MS AB SCIEX 4500 SERIES MASS SPECTROMETERS

The new AB SCIEX 4500 Series takes the legendary API 4000™ platform and intelligently re-engineers it to set a new benchmark for reliable quantitation – and a minimum 10X increase in sensitivity over competitive triple quads in the same class. A new level of confidence for screening applications. The 4500 Series is available with unique QTRAP® Technology to offer 100X more full-scan sensitivity over basic triple quads for simultaneous quantitation and library searching. A complete solution. The AB SCIEX Accelerated Lab Integration™ Packages now merge LC/MS/MS with application specific software,...

AB SCIEX 4500 Series The LC/MS/MS workhorse, intelligently re-engineered. For research use only. Not for use in diagnostic procedures. The AB SCIEX 4500 Series is next-generation technology from the leaders in mass spectrometry. Redesigned from the foundation of our industry standard triple quadrupole mass spectrometers, the 4500 Series introduces a new era of LC/MS/MS performance. An era defined by fast, precise quantitation and ultra-fast triple quadrupole scan speeds – an era that’s ideal for UHPLC. Fast LC demands short dwell times The world’s most sensitive ion trap With 1ms dwell times...

Pushing the limits of mass spectrometry AB SCIEX customers expect maximum uptime and a system that can easily handle the most difficult matrices. The 4500 Series fulfills those expectations – with new levels of dependability and consistency built into the system. The Turbo V™ source and Curtain Gas™ interface set the benchmark for reliability. And the proven QJet® ion guide, eQ™ electronics, Qurved LINAC® collision cell, and AcQuRate™ pulse counting detector set new standards for system robustness.

Drive productivity The Turbo V™ source provides high- sensitivity analysis over a wide range of flow rates with quick-change APCI and TurbolonSpray® probes. From 50 uL/min to 3 mL/min, the Turbo V Source is the perfect match for narrow bore, standard bore and UHPLC flow rates, delivering unprecedented desolvation and stability for even the toughest high-flow applications Ultimate sensitivity and simplicity The patented QJet® ion guide improves ion containment and operates at high pressure, providing better collisiona focusing to enhance ion transmission for ultimate sensitivity. The proven design...

The future path of LC/MS/MS quantitation The AB SCIEX 4500™ Series brings together the latest hardware from the world’s best selling triple quadrupole family, and adds next-generation, ultra-fast and sensitive Linear Accelerator™ Trap functionality. Delivering unmatched quantitative and qualitative analysis, the 4500 Series enables productive, time-saving workflows that simply cannot be done with other mass spectrometry systems. AcQuRate™ Pulse Counting Detector The AcQuRate™ pulse counting detector combined with a pulse overlap correction algorithm, enabling more accurate and precise ion detection...

Optional QTRAP® technology Bringing LINAC® technology to the Q3 linear ion trap greatly improves the extraction efficiency to yield up to a 100 x gain in sensitivity in ion trap scan modes. Now take full advantage of the 20,000 Da/s scan speeds with full scan linear ion trap sensitivity 100X more sensitive than triple quad full scan experiments for greater confidence in qualitative workflows. Improved excitation efficiencies and reduced ion cooling and fragmentation times produce superior MS3 qualitative results and provide unprecedented selectivity for the most challenging analytical assays....

The AB SCIEX Triple Quad 4500 System ™ Reliable, robust, definitive quant For real-world commercial labs who need a fully integrated LC/MS/MS workhorse, they can trust, hour after hour, day after day. The Triple Quad 4500 system is built to match the robustness and reliability established by the API 4000™ system and has been enhanced in performance across all critical parameters: sensitivity, dynamic range, linear Ion trap performance, scan speed and footprint. • Improve MRM sensitivity by 10X vs. competitive triple quads in the same class • Optimize your integration with UHPLC strategies with...

Robustness and performance for any application Drug monitoring research 204 pesticide standard (1 ng/mL) Intensity, cps QT4500 spike6 NRTI.rdb (FTC 1): "Linear" Regression ("1 / x" weighting): y = 0.00204 x + -0.00116 (r = 0.9988) 10.5 Contaminant analysis 2500 Analyte Conc. / IS Conc. Emtricitabine Didanosine Zidovudine Stavudine With the fastest dwell times of any LC/MS/MS the 4500 series is ideally suited for multi component contaminant analysis as these data demonstrate with the detection of over 200 pesticides at 1ng/mL. The faster electronics and the intelligent Scheduled MRM (sMRM), permits...

Analyst method converter Rapidly transfer your workflows Developed a method? Let Analyst transfer it for you. In moving from one mass spectrometery platform to another, AB SCIEX is conscious of the fact that customers need to consider the impact of method transfers on resources, timelines and data quality. For this reason, AB SCIEX has created the Convert Methods Utility. This innovative tool takes pre-developed Analyst MS-methods established on the 3200, 4000, 5000 and even 5500 platforms and updates them instantly for use with the all new 4500 Series for seamless, accelerated integration. Simply...

One touch productivity Take full advantage of all the speed and power of the 4500 Series. Powerful, workflow-driven software ties everything together to deliver a new benchmark in efficiency, throughput, and productivity. Industry-standard Analyst® Software utilizes the intelligent Scheduled MRM™ algorithm to make the method setup of over 1000 analytes in a single LC analysis straightforward and simple while still generating exceptional quantitative and brilliant qualitative results. Save time, without compromising MRM data processing MultiQuant™ Software is Simplified, preconfigured testing...