Brochure: AB SCIEX TripleTof 4600 System, The Accurate Mass Workhorse
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AB SCIEX TRIPLETOF ™ 4600 SYSTEM The accurate mass workhorse AB SCIEX TRIPLETOF ™ 4600 SYSTEM

The new AB SCIEX TripleTOF™ 4600 System extends the TripleTOF family, making the ground-breaking features of the TripleTOF™ 5600 system – sensitive, high-resolution, accurate mass MS and MS/MS data acquired at unrivaled speeds – available in a value-priced, workhorse platform. Comprehensive workflows in any research or routine analytical testing laboratory For applications ranging from drug metabolism, proteomics, metabolomics and lipidomics to general unknown screening in food, environmental or forensic toxicology samples, the TripleTOF 4600 provides the most comprehensive, and most...

Pushing the limits in mass spectrometry AB SCIEX has taken accurate mass technology and made it accessible to any laboratory that requires maximum uptime, ultimate robustness, and high accuracy in compound identification and quantitation, all in an easy-to-use, value-priced platform. The AB SCIEX TripleTOF 4600 System combines the world’s fastest acquisition rates with intelligent acquisition strategies to give analytical scientists a dependable accurate mass LC/MS/MS samples. Typical operating mass resolution of >25,000 FWHM workhorse for routine comprehensive analysis of complex accuracy...

One system, flexible workflows For the first time, pharma, academic and routine analytical testing scientists can integrate comprehensive qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform, providing faster and more accurate answers to “what is in the sample, how much is there, and does it change?” QUALITATIVE ANALYSIS QUANTITATIVE ANALYSIS EXPLORE Explore complex samples in greater depth: Select up to 50 precursors – and generate high resolution and high mass accuracy MS/MS spectra in LC High resolution MS/MS a second using powerful...

High resolution, accurate mass MS PROFILE Profile samples for quant and qual in a single run: Quantify virtually every compound in the sample High resolution, accurate mass MS/MS with high-resolution MS quantification and fast chromatography; confirm compound identity with highresolution, accurate-mass MS/MS; then mine the data for the information you need. Quantitative and qualitative information in a single run • Combine high-resolution MS quantification with high-resolution MS/MS ID confirmation Quantify every compound—even under fast LC conditions Re-visit data for further interrogation...

Inspired engineering Beginning with the best-in-class quantitative performance of the AB SCIEX Triple Quad™ 5500 system, AB SCIEX researchers developed the Accelerator TOF™ Analyzer to deliver high resolution at the speed and sensitivity required to maintain the precision and limits-of-quantitation associated with MRM. This innovation is featured in the AB SCIEX TripleTOF™ 4600 System – the newest addition to the AB SCIEX quadrupole TOF family of products. Automated Calibrant Delivery System A utomated Calibration Delivery system allows easy, Next generation eQ™ electronics enable faster...

• 40 GHz four channel TDC and detector provide highest sampling speeds and maintains high resolution – even at low mass • 30kHz accelerator for highest acquisition rate • New entrance optics improves ion beam focusing post LINAC Accelerator TOF ™ Analyzer for improved resolution and sensitivity • 10kV acceleration voltage for optimal resolution • High transparency grids throughout for minimal ion loss • Two-stage ion reflector compensates for energy dispersion to maximize resolution

One touch productivity Take advantage of fast data acquisition, and get reliable information from your accurate mass data, using powerful, workflow-driven software solutions. Whether your application is drug discovery and metabolism, food and environmental contaminant analysis, forensic toxicology sample screening, or proteomics discovery and quantitation, intelligent software solutions help you get the most information from a single analysis. Drug Metabolism with General Unknown Screening Protein identification and quantitation MetabolitePilot™ Software with PeakView™ Software with...

Accurate mass performance delivered in a workhorse platform Keep the ‘accurate’ in accurate mass data acquisition for Multiple mass defect triggered IDA (Information Dependent hour-after-hour performance Acquisition) improves efficiency and reduces the need for multiple AutoTune and EasyMass provide high confidence in mass accuracy for long sample batches, producing reliable data hour-after-hour, day-after-day. injections to get comprehensive information. Mass defect can be applied for specific mass ranges and multiple mass defects. Neutral loss triggered IDA provides unique specificity by...

The power of accurate mass for any application Confident metabolite identification Use MetabolitePilot™ Software for Integrated MS/MS Interpretation to perform The Correlation Workspace allows qualitative and quantitative data visualization to structural editing and automatic fragment assignments, directly within the results assess metabolite kinetics or to review metabolites across species. Comparative unknown screening analysis in food and environmental samples 2e5 1e5 0e0 Easily identify chemical contaminants in a variety of different food and environmental samples, and perform both...

Screen forensic toxicology samples for drugs of abuse, analogs, and metabolites hundreds of drug compounds in a single run using PeakView® Software with the XIC Manager. Identify compounds by searching against a library, and get confident identification by mass error, retention time, and MS/MS purity score. TOF-MS/MS Terfenadine Purity Score 96.8% Elevate biologics analysis and discovery proteomics workflows 872.5195 Accurately determine the molecular weight of a protein using By coupling the high speed, high resolution MS/MS acquisition capabilities of the TripleTOF™ 4600 System high...