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Brochure: Discovery Proteomics


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Brochure: Discovery Proteomics - 1


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Brochure: Discovery Proteomics - 2

Unraveling the complexity of the proteome in a cell or organism makes protein discovery research challenging. AB SCIEX has a comprehensive portfolio of cutting edge solutions that address that challenge. Our instrumentation, software, reagents, and workflows enable you to dig deeper into the proteome to identify low abundant proteins and convert complex data into biologically relevant results.

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Starting with the right tools The AB SCIEX TOF/TOF™ 5800 System combines high-sensitivity and ultimate flexibility with MALDI ease of use. The AB SCIEX TripleTOF™ 5600 System delivers uncompromising speed, sensitivity and resolution for more high-quality protein identifications than ever before. Together our solutions deliver it all with powerful, intuitive software. Eksigent cHiPLC ™ –nanoflex System Eksigent nanoLC–Ultra ™ System Eksigent nanoLC ™ –MALDI spotting system featuring the ekspot ™ spotter AB SCIEX TripleTOF ™ 5600 System AB SCIEX TOF/TOF ™ 5800 System

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The protein research pipeline Protein research is a continuous pipeline. Typically beginning with a small number of samples, hypotheses are tested and key proteins are identified and characterized. These proteins can then be verified and validated in greater numbers of samples to account for biological variation. Finally, assays are developed for routine detection of the protein. Protein research pipeline tens AB SCIEX TOF/TOF ™ Systems AB SCIEX Triple TOF ™ Systems AB SCIEX QTRAP ® Systems Easily integrate with MS-based chemistries and kits

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It all starts with discovery Powerful hardware solutions Establish the foundation for high-quality protein discovery with the world-class performance and walk-up usability of our TripleTOF™ 5600 and TOF/TOF™ 5800 systems with Eksigent LC technologies. Timesaving software Identify and quantify proteins of interest, as well as their biologically relevant isoforms and PTM’s with ProteinPilot™ Software. HARDWARE Label-free discovery Quickly uncover statistically interesting peptides with the powerful visualization capabilities of MarkerView™ Software. Revealing reagents Highlight proteins of...

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Expanded protein discovery capabilities The AB SCIEX TOF/TOF™ 5800 System The TOF/TOF™ 5800 System is the fastest, most sensitive MALDI platform available for protein identification—from fast, automated analysis of 1D and 2D gel spots to in-depth identification and expression analysis of complex samples. The TOF/TOF™ 5800 System features a simplified workflow for fast, definitive protein identification that is ideal for multi-user environments and gel spot analysis • Variable rate 1000 Hz laser provides fast acquisition rates Self-cleaning MALDI source increases instrument uptime The...

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Greater depth of coverage using the LC MALDI workflow 3 replicate LC MALDI runs, 5% global FDR. The path to greater productivity: Innovative technology and intelligent design combine Maximum depth of coverage: The LC MALDI workflow using the Eksigent nanoLC™– to bring new levels of efficiency and reproducibility to the LC MALDI workflow. MALDI spotting system and the ekspot™ spotter maximizes depth of peptide coverage by separating mass analysis from the time constraints of LC. Compatible with industry standard labeling chemistries iTRAQ Reagents Compare and quantitate protein expression...

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In-depth discovery without compromise The AB SCIEX TripleTOF™ 5600 System The sensitivity of the TripleTOF™ 5600 System enables a new level of information-dependent acquisition (IDA) speed—and identifies a higher number of high-confidence proteins • Identify: Acquire up to 50 MS/MS spectra per second using SmartSpeed™ Acquisition without sacrificing resolution, mass accuracy, or dynamic range • Profile: Perform quant and qual in a single run using high-resolution MS with fast MS/MS confirmation • Quantify: Target subsets of previously detected peptides and generate initial verification data...

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The NanoLC-Ultra—world-leading nano-chromotography The NanoLC-Ultra uses split-less, nanoscale Microfluidic Flow Control (MFC) technology to achieve fast flow measurement in combination with automatic feedback to a regulated pressure source. As a result, the system generates accurate and reproducible flow rates with a resolution better than 1 nl/min and retention time reproducibility of less than 0.5% RSD. A maximum pressure of 10,000 psi enables the use of longer columns—or columns packed with smaller particles—for the analysis of highly complex proteomics samples. The cHiPLC-nanoflex...

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ProteinPilot™ Software ProteinPilot™ Software sets a new standard for high-quality protein identification and biomarker discovery by enabling all users, regardless of experience to obtain reliable, understandable results. • Get more peptide identifications in your samples using the powerful Paragon™Algorithm. • Report reliable, defensible protein identification results with industry leading Pro Group™ Algorithm for protein inference analysis and built-in False Discovery Rate (FDR) calculations. A faster easier way to high quality results. Enter the sample information and experimental goals...

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MarkerView™ Software MarkerView™ Software facilitates label-free discovery using any AB SCIEX mass spectrometer platform, both ESI and MALDI workflows. • Find peaks and align mass and retention time across samples. Determine up or down regulated endogenous proteins and peptides using statistical analysis tools. Quickly spot interesting features with informative, interactive data visualization graphics. Uncover relationships among peptides: The Principal Component Variable Grouping Profile of 350 variables in group 1 From the associated MS and MS/MS data, peptides with differential behavior...

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