Multiplex your most important genetic assays on one platform GenomeLab GeXP Genetic Analysis System Blood Banking Capillary Electrophoresis Centrifugation Flow Cytometry Genomics Lab Automation Lab Tools Particle Characterization

All on One Platform Perform your ideal genetic assays on one platform A broad spectrum of applications Gene Expression Sequencing SNP Analysis STR Analysis AFLP* MLPA** Complement your gene expression analysis with LOH studies. Confirm your SNP analysis results by sequencing. Combine MLPA genomic results with quantitative gene expression for the full story. Do all this on one platform, with one capillary array, one gel and one software. The GenomeLab GeXP supports a variety of applications, including DNA sequencing and fragment analysis. Furthermore, this flexible system allows you to run more...

High-throughput quantitative gene expression. With the capacity to analyze up to 30 genes per reaction, the scalable GenomeLab GeXP enables the examination of up to 5,760 data points unattended in 24 hours. Cost-effective and time-saving gene expression. lowering PCR expenses and improving efficiency, the multiplex By power built into the GenomeLab GeXP System enables you to analyze up to 30 genes per sample at a dramatically reduced cost per gene expression result with considerable time savings. High accuracy and reproducibility you can trust. With unrivaled linearity (R2 > 0.99 for most genes),...

All on One Platform The eXpress profiling process for gene expression analysis Simplified for multiplex capability Beckman Coulter’s GenomeLab GeXP Genetic Analysis System uses a simplified two-step multiplex PCR process for multiplexing biomarkers in gene expression assays. Each multiplex integrates biological controls in the same well as target genes and reference (housekeeping) genes. This approach not only reduces reagent consumption, but also eliminates pipetting variation and minimizes the need for technical replicates. The true flexibility of the system is the ease and specificity of panel...

PCR Multiplex PCR with chimeric and universal primer sets Universal tag forward sequence Gene specific forward sequence S amples are ready to load on the GenomeLab GeXP Genetic Analysis System without the need for chemistry clean-up. The multiplex PCR amplified fragments are separated and evaluated using the eXpress Profiler software. The multiplex reaction contains the cDNA for all genes of choice tagged with a 5’ end universal sequence. Two types of primers are present in the reaction: 1) Chimeric primers contain a gene-specific sequence with a tag at the 5’ end universal sequence. They are...

Multiplexed gene expression delivers high sensitivity, accuracy and precision The GenomeLab GeXP produces gene expression data with superb linearity. A highly linear correlation between the amount of RNA and gene expression level is generated for each gene in a multiplex with an average correlation coefficient (R2) well above 0.99. Relative accuracy (RA) of GeXP in detecting 0.5-fold change in the amount of Human Breast CancerP\ex control RNA The GenomeLab GeXP is sensitive enough to precisely detect even small changes in gene expression. The 0.5-fold increases in RNA concentration are consistently...

Gene expression eXpress Profiler software express Profiler GenomeLab eXpress Profiler takes the uncertainty out of assay design by providing fast, automated primer design, multiplex development and calculation of relative gene expression values. eXpress Analysis With the eXpress Analysis module, fragment data is easily identified and associated with the design file using the software's QC functionality. Report output from the eXpress Analysis module can be imported into the eXpress Map for visualization as a high- density array image (heat map). This analysis can also be imported into spreadsheet...

All on One Platform Resolve complex sequences with high- quality information Sequencing Other System Beckman Coulter’s Sequencing Chemistries Using a novel approach to chemistry, our system features unique DNA sequencing reagents – including linear polyacrylamide gel (LPA), coated capillaries, dITP chemistry and near-infrared dyes – coupled with online denaturation. This results in less correction, more meaningful raw data and higher-quality final analyses. In this example, the GenomeLab GeXP is compared with another automated sequencing system for the completion of a problematic human genome...

Multiplex fragment analysis results — whether you’re genotyping, SNP scoring or quantifying microsatellite instability, the accurate and timely assignment of alleles can dramatically impact your lab’s productivity. Compatible with assays such as MLVA or MLPA, multiplexing reduces time and cost and uses fewer samples. We developed the GenomeLab GeXP Genetic Analysis System to provide high-precision DNA sizing and sophisticated software algorithms with these processes in mind. SNP Analysis The Genomelab SNPStart Primer Extension Kit is based on single base primer extension technology, a gold standard...

All on One Platform A genetic analysis solution that meets your needs The GenomeLab GeXP utilizes single or dual plates with the sample tracking technology option to provide an advanced, industry-leading genetic analysis solution. The result is a fully automated, high-resolution system that adapts well to daily workflow changes in sample type and complexity. The GenomeLab GeXP Genetic Analysis System has the ability to process and track samples in two Long- life lasers On-column, laser-induced fluorescence with auto capillary alignment ensures sensitive and reliable detection. Long-life diode...

A complete process solution As a scientist, you understand the challenges of working with limited amounts of sample, tight deadlines and complex studies. Beckman Coulter has a better way…a complete solution, all on one platform. Our integrated GenomeLab solutions and team of experts will help you to deliver the high-throughput and quantitation needed for your application. Simply put, our systems help eliminate the bottlenecks and put you on the fast track to getting the results you need. Automated nucleic acid isolation and purification Agencourt sample preparation reagents, coupled with our...