A new dimension in selectivity SCIEX SelexION differential mobility spectrometry

Advanced separation for challenging analytes Advanced performance SCIEX SelexION differential mobility spectrometry (DMS) is an effective ion mobility separation tool for improving data quality in the quantification and characterization of challenging samples requiring advanced analytical selectivity. Enhanced selectivity SelexION DMS delivers a new dimension of selectivity and performance for any applications requiring the separation of isobaric species, isolation of challenging co-eluting analytes and reduction of high background noise. Transformational analytical power SelexION DMS brings...

• Quickly add SelexION DMS) to your mass spectrometry system with a small, easily interchangeable cell • Increase peak separation power further through the use of chemical modifiers • Meet analytical standards for quantitative reproducibility and robustness • Quantitative and qualitative workflows • Match cycle and run times with multi-component analysis and UHPLC time scales • On demand operation can be turned off and on as needed without removing hardware

The tool to take on your most challenging assays No other ion mobility separation tool has the reproducibility, robustness and ease of use to deliver highly selective and sensitive quantitative and qualitative analyses, within a UHPLC time scale – all on the most sensitive SCIEX Triple Quad, QTRAP and TripleTOF systems. Perform a gas phase differential ion mobility separation within the planar mobility cell, based on the ion’s size and shape, prior to entering the mass analyzer where the compounds are further separated by m/z ratios. Separate ions based on the difference between their unique...

SelexION+ DMS enhanced selectivity in a robust and elegantly simple package The SelexION+ DMS is enhanced with a jet injector lens to help accelerate ions and deliver up to a 2x improvement in ion transmission. Currently available for use only on the new SCIEX 6500+ series mass spectrometers, the SelexION+ ion mobility cell is enhanced by a jet injector that reduces the ion residence time within fringing fields at the DMS inlet. This increases the size of the acceptance region, providing a 2-fold increase in transmission over the standard SelexION DMS. 4000 replicate injections of methamphetamine,...

A clear difference A. In some cases, compound identification via automated MS/MS library searching might be challenging due to the presence of isobaric interferences. B. When SelexION DMS is employed, isobaric interferences are removed prior to analysis by MS/MS. In the example presented here, the library match score for fentanyl increases from 29% to 88% when SelexION DMS is employed. Use discrete compensation voltage steps to subfractionate your proteomic sample at the sample introduction stage. Easily fine tune your fractionation experiment on the fly by adjusting SelexION parameters. Using...

Achieve unprecedented quantitative sensitivity Isobaric lipid molecular species separation Lipid classes can be separated with DMS, an orthogonal dimension to mass, to remove isobaric interferences. This provides specificity — higher confidence in lipid species assignment to generate more accurate biological insights, and simplicity. DMS also allows easy development of optimized lipid-specific assays without the use of complex, lengthy chiral chromatography. A. Somatostatin, a cyclic peptide with poor MS/MS fragmentation is acquired using a MIM (Q1 819.7 -> Q3 819.7) assay in rat plasma. High...

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