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SCIEX TRIPLE QUAD™ 5500 SYSTEM

SCIEX TRIPLE QUAD™ 5500 SYSTEM

Product catalog summary

Overview of the SCIEX Triple Quad™ 5500 System
The SCIEX Triple Quad™ 5500 System is designed for high sensitivity and robustness in complex matrices, ideal for DMPK and ADMET studies. It is effective in multi-component quantitation for environmental studies, targeted quantitative proteomics, clinical research, and food and beverage analysis. The system integrates fast eQ™ electronics and patented technologies with Analyst® Software to enhance performance.

Quantitative Performance
The system features ultra-fast scan speeds and the Scheduled MRM™ algorithm, maximizing dwell time without sacrificing accuracy and precision. This enables monitoring of numerous MRM transitions, achieving lower limits of quantitation (LLOQ), excellent coefficient of variation, and linear performance across a dynamic range.

Software Integration
Analyst® Software, combined with the Scheduled MRM™ algorithm, enhances efficiency and productivity. It supports pharmaceutical bioanalysis, biomarker analysis, and screening of pesticides and personal care products, allowing measurement of thousands of analytes in a single LC analysis.

Technology and Reliability
The system is built for maximum uptime and productivity, capable of handling thousands of samples weekly. The Curtain Gas™ interface and QJet® ion guide enhance robustness, with consistent quantification results and low % CV in repeated tests.

Ion Sources
The system offers interchangeable ion sources for various applications and flow rates. The Turbo V™ source supports high-sensitivity quantitation across a range of flow rates, while the NanoSpray® III ion source facilitates nanoflow chromatography with high sensitivity and stability.

Advanced Electronics and Detection
Fast eQ™ electronics enable rapid polarity switching and improved ion containment. The AcQuRate™ Pulse Counting Detector ensures precise ion detection over a wide dynamic range, while the QJet® Ion Guide and Qurved LINAC® Collision Cell enhance ion transmission and analysis speed.

SelexION® Technology
SelexION® technology adds selectivity, supporting highly selective and quantitative LC-MS/MS workflows. It allows for differential ion mobility separation, enhancing resolution and reproducibility, and can be integrated or removed without breaking vacuum.

Introduction to SelexION Technology
SelexION technology, integrated with the SCIEX QTRAP 5500 System, offers enhanced reproducibility, robustness, and stability for LC-MS/MS workflows. It improves signal-to-noise ratios and selectivity for challenging samples through differential ion mobility separation (DMS).

Performance and Reproducibility
The technology demonstrated a coefficient of variation (% CV) of less than 7% over 66 hours of analysis for Buprenorphine and Clenbuterol in human plasma. DMS effectively reduces high chemical noise, enhancing detection capabilities significantly.

Operational Features
SelexION technology allows for on-demand operation, easy setup or removal within 2 minutes, and compatibility with multi-component analysis and UHPLC run times. It separates ions based on mobility differences, enhancing resolution with chemical modifiers.

Software Solutions

Cliquid® Software: Simplifies routine testing with pre-configured tests and a user-friendly interface, accelerating LC-MS/MS adoption.
DiscoveryQuant™ Software: Enhances drug candidate analysis efficiency for high-throughput ADME studies.
MultiQuant™ Software: Facilitates quantitative data processing for large datasets, supporting protein/peptide workflows.
Analyst® Software: Provides comprehensive instrument control and data analysis, enhancing performance and ease of use.

Customer Support
SCIEX offers world-class customer support, ensuring access to the latest updates and solutions to maximize lab productivity.

Catalog excerpts

High Levels of Sensitivity and Robustness for Complex and Demanding Matrices SCIEX TRIPLE QUAD™ 5500 SYSTEM

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The SCIEX Triple Quad™ 5500 System is designed to deliver a high level of sensitivity and robustness for even the most complex matrices. The system offers the performance required by even the most demanding DMPK and ADMET studies and excels at multi-component quantitation required by environmental, targeted quantitative proteomics, clinical research, and food and beverage applications. Built from the ground up on fast eQ™ electronics, the system combines patented technologies with powerful Analyst® Software. Built on a Legacy of Quantitative Performance The SCIEX Triple Quad™ 5500 System was...

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Sources Rugged, reliable, easily interchangeable ion sources are available for a wide range of applications and flow rates to suit your analysis needs. Rapid source change-over extends system flexibility with minimum downtime. All temperature, gas, and electrical connections are fully integrated into the source housing—no extra lines to attach, and no lost time. Magnetic connections automatically detect the hardware change and alert the software. Turbo V™ source enables highest-sensitivity quantitation over a wide range of flow rates with quick-change APCI and TurboIonSpray® probes. From 50 μL/min...

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The future path of triple quad technologythe gold-standard for quantitation technology The SCIEX Triple Quad™ 5500 System combines innovative technology with the reliability of the world’s best-selling triple quadrupole family for unmatched quantitative performance. Finally, a reliable system with fantastic sensitivity and speed which perfectly complements UHPLC and fast LC to enable productive, time-saving workflows that produce superior quantitative results every day. AcQuRate™ Pulse Counting Detector The AcQuRate™ detector is the latest in detector technology combined with a patented pulse...

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Reproducible, Robust and Easy to Use SCIEX SelexION® SelexION® technology supports highly selective and quantitative LC-MS/MS workflows with the SCIEX 5500 Triple Quad™ and QTRAP® 5500 Systems. • Perform a gas phase differential ion mobility separation within the planar ion mobility cell based on the size and shape of the compound prior to entering the mass analyzer Differential ion mobility separation technology – a new dimension in selectivity • Achieve robust reproducibility for regulated bioanalysis standards • Enhance resolution with integrated chemical modifiers • Separate ions based on...

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One touch productivity Powerful, workflow-driven software ties everything together to deliver a new benchmark in efficiency, throughput, and productivity to let you take full advantage of all the power that the SCIEX Triple Quad™ 5500 System puts at your fingertips. And the latest version of industry-standard Analyst® Software utilizes the intelligent Scheduled MRM™ algorithm to make the method setup of over 1000 analytes in a single LC analysis straightforward and simple while still generating exceptional quantitative results. ONE TOUCH PRODUCTIVITY SOLUTIONS Cliquid® Software Cliquid® Software’s...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.

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