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See how SelexION® Differential Mobility Technology

See how SelexION® Differential Mobility Technology

See how SelexION® Differential Mobility Technology

Product catalog summary
Introduction to SelexION Technology
SelexION technology offers an orthogonal sample separation method to mass separation, enhancing the analysis of complex samples by reducing noise and interference. This technology is compatible with SCIEX Triple Quad™, QTRAP®, or TripleTOF® Systems, providing solutions to common analytical challenges.

Key Challenges Addressed by SelexION DMS Technology
  • Matrix Interferences: SelexION DMS technology enhances quantitative analysis by separating analyte ions from overlapping matrix interferences, allowing for more selective detection.
  • Isobaric and Isomeric Species Separation: The technology improves the identification of isobaric species by separating samples prior to MS analysis, aiding in accurate lipid class quantitation and identification of peptide modifications.
  • Background Noise Reduction: By reducing background noise, SelexION DMS enhances lower limits of detection, allowing compounds to be detected at lower levels.
  • Sample Preparation Efficiency: The technology simplifies sample preparation procedures by reducing the need for complex HPLC conditions, isolating compounds of interest prior to MS detection.
  • Assay Diversity and Throughput: SelexION DMS enables assay diversity without impacting instrument downtime, as it can be installed or removed in less than 2 minutes without breaking vacuum.

Application Areas and Benefits
  • Lipidomics: Resolves multiple lipid classes within complex matrices, enabling confident identification and accurate quantitation by MS/MS.
  • Food and Environmental Testing: Provides an additional level of separation to reduce background noise and interferences, ensuring robust detection of contaminants.
  • Peptide and Protein Quantitation: Enhances analysis in complex matrices, improving sensitivity and selectivity for large molecule targets.
  • Forensics: Reduces chemical noise and improves quantitative accuracy for complex forensic analytes.
  • Small Molecule Bioanalysis and Metabolism: Offers orthogonal separation to reduce noise and interferences, facilitating robust bioanalytical methods without complex procedures.

Conclusion
SelexION Differential Mobility Spectrometry provides a new level of selectivity, addressing common analytical challenges across various application areas.
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Catalog excerpts

See how SelexION® Differential Mobility Technology-1

See how SelexION® Differential Mobility Technology addresses your biggest analytical challenges Simplify. Clarify. Quantify SelexION technology delivers a sample separation that is orthogonal to mass separation for your most challenging samples. Instead of returning to method development, SelexION DMS technology allows you to reduce noise and interference from your sample so you can measure the molecules that count. Learn how you can overcome these 5 common challenges by incorporating SelexION DMS separation on your SCIEX Triple Quad™, QTRAP®, or TripleTOF® System Detection Challenges due to Matrix Interferences? DMS technology can increase your confidence in quantitative analysis free from matrix interferences Separate analyte ions from overlapping matrix interferences within complex samples, allowing for more selective detection of your compound of interest and worry free quantitation Inability to Confidently Separate Isobaric and Isomeric Species? DMS technology can expand your ability to identify isobaric species with confidence Address isobaric interferences by separating your sample prior to MS analysis to improve identification, such as separating phospholipid samples into sub-classes for accurate lipid class quantitation, or identifying differentially localized modifications on the same peptide sequence. Quantitation Limits Hindered by High Background Noise? DMS technology can reduce overall background noise to enhance lower limits of detection Reduce or remove background noise signal using the separation power of DMS, allowing your compound of interest to be detected at lower levels than previously possible. Lengthy Sample Preparation Procedures? DMS technology can save you time and energy during sample preparation If you’re required to perform lengthy and complex sample preparation procedures and HPLC conditions to separate your analyte of interest from interfering sample matrix components, simplify your prep procedures and rely on DMS orthogonal separation to reduce background and isolate your compound of interest prior to MS detection Looking to Increase Assay Diversity without Decreasing Throughput? DMS technology can enable assay diversity without impacting instrument downtime Unlike other differential ion mobility approaches, the SelexION DMS device is not permanent. It takes less than 2 minutes to install without breaking vacuum on your system. This means you can use SelexION for your challenging assays, and remove it when it’s not required with minimal impact to your instrument uptime. SelexION mobility provides a new dimension in select

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See how SelexION® Differential Mobility Technology-2

Discover the benefits of SelexION® Differential Mobility Spectrometry for these selected application areas Conquer the challenges of common workflows Food and Environmental Testing Resolve multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Compounds required to be analyzed by regulatory agencies may be difficult to reproducibly detect due to complex matrices. You’ll have an additional level of separation to reduce background noise and interferences to enable robust and reproducible...

 Open the catalog to page 2

Archived catalogs

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  2. SelexION™

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  3. 3200MD

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  4. NanoLC™ 400

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  5. MPX™

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  6. SCIEX VISION

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  7. SelexION

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