Liquid Chromatograph Mass Spectrometer

Accomplishes Both High Sensitivity and Ultra-High-Speed Detection Equipped with a heated ESI probe, the LCMS-8045 has the highest* sensitivity in its class. The instrument is capable of providing accurate and stable data over long periods of time. The inclusion of Shimadzu's ultra-high-speed high-voltage power supply enables the world's fastest* scan speed (30,000 u/s) and polarity switching time (5 ms). High-speed acquisition benefits the laboratory by reducing run times for increased throughput, and also shortens method development time. * As of August 2016, according to a Shimadzu survey Superior...

Ionization Unit Designed without cables or tubes; utilize a one-touch lever to perform simple attachment and detachment of the unit. DL (Desolvation Line) Perform maintenance without breaking vacuum. Qarray™ Patented Qarray ion guide is designed to effectively focus ions over a wide m/z range by overlapping multiple electric fields. UFsweeper™ II Collision Cell The UFsweeper II is a high-sensitivity, high-speed collision cell that features improved ion focusing by using high-speed ion transport technology. This yields better product ion transmission in the collision cell, maintaining signal intensity...

High Performance for a Variety of Applications Veterinary Drugs Nitrofuran metabolites in fish Nitrofurans are a class of synthetic antibiotics. The use of nitrofurans for edible animal and fishery products is banned in many countries. The chromatogram below shows the recovery of nitrofuran metabolites from fish using the LCMS-8045. Excellent linearity and accurate quantitative results ranging from 0.05 to 20 ng/mL were obtained. The LCMS-8045 is shown to be an excellent platform for routine high-sensitivity analysis in challenging matrices. Calibration range, accuracy and limit of detection (LOD)...

Water Quality Analysis High-sensitivity analysis of 21 pharmaceuticals and personal care products in less than eight minutes Pharmaceutical and personal care products (PPCPs) encompass a family of compounds used by individuals for health and cosmetic purposes. As populations increase, and the use of these products increases, PPCPs will become a significant threat to our water supply. The LCMS-8045 is capable of trace-level quantitation of many PPCPs without extensive sample preparation. The limit of detection (LOD) and limit of quantitation (LOQ) for 21 PPCPs * Limit of detection (LOD) was calculated...

Consistent High-Sensitivity Performance Robust Ion Source and Sample Introduction System Shimadzu's MS interface includes a high-sensitivity heated ESI source, heated capillary sample introduction, and proprietary ion transfer optics. These design features combine to produce robust MS performance. 12,000 plasma samples were injected over 25 days (over 480 samples per day). Picogram levels of alprazolam were analyzed with an RSD of 3.42%. 5 ng/mL Alprazolam spiked in protein-crashed human plasma extracts (IS: 5 ng/mL alprazolam-d5) m/z 309.15 > 205.1 1.5 Area ratio Column replaced after 7,500...

Newly Designed Ionization Unit Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS ™ units, allowing for easy maintenance. Easy System Maintenance Reduces Downtime As with Shimadzu’s other triple quad systems, maintaining the LCMS-8045 is simple. Replacing the desolvation line (DL) and ESI capillary is quick and easy. Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability....

Smart Software for Anyone Doing LC-MS/MS LabSolutions Connect™ LabSolutions Connect is the smart way to work for all routine laboratories. Simplifying workflows to run samples on the LC-MS/MS with tools to help MRM optimization. Get Better Results Laboratories with the need for expanding target compound panels or building up new methods also need to consider how to get the highest sensitivity without manual compound optimization. The automated MRM optimization tool, which is part of the LabSolutions Connect platform, delivers MRM transitions for quantitation and for MRM Spectrum for library searchable...

LabSolutions Insight™ Rethinking Quantitative Data Review LabSolutions Insight has powerful data mining and analytics capabilities for reviewing LC-MS/MS results. It is designed to support review-by-exception enabling quality rules to identify exceptions quickly. LabSolutions Insight now has the added capability to work seamlessly with the LabSolutions DB/CS environment and audited regulatory requirements, it also has the flexibility to adapt to different reporting workflows with multiple results files. The new Insight software also supports library identification by either full scan or MRM spectrum...

Compound Identification LabSolutions Insight Library Screening LabSolutions Insight offers MS/MS library search capabilities. Instrument parameters and MS/MS library spectra are available to deliver faster data acquisition, higher data quality, and enhanced identification. Shimadzu’s LabSolutions Insight software offers easy viewing of the compounds of interest, including structural information, retention time and library similarity score. LabSolutions also enables you to produce high-quality results without the need to define a threshold value to trigger a spectrum, decreasing the chance of false...

Shimadzu Nexera™ Series Shimadzu's unique approach to delivering high-quality, high-speed LC-MS/MS analysis combines the Shimadzu UHPLC and LCMS-8045 as a seamlessly integrated system. Analysis Cycle Time Less Than 10 Seconds The SIL-40 autosampler can process the entire injection cycle time in as little as seven seconds, twice as fast as the previous model. In addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically increase analysis throughput. Nexera series 8 injections can be completed within 1 minute (Caffeine) Pharmacokinetic...