LIAC
16Pages

Sordina IORT Technologies

“IntraOperative Radiation Therapy (IORT) in its broadest sense refers to the delivery of irradiation at the time of an operation. IORT evolved as an attempt to achieve higher effective doses of irradiation while dose-limiting structures are surgically displaced”. “IntraOperative irradiation (IORT) refers to delivery of a single dose of irradiation to a surgically exposed tumor or tumor bed while the normal tissues are protected from the irradiation either by retracting the mobilized tissue or by shielding the anatomically fixed tissues. IORT has traditionally been performed by using an...

TRANSPORT INTO STRETCHER ELEVATOR: the dimensions are such that LIAC can be easily transported to the operating room through the use of any stretcher elevator. FLEXIBLE S1 EABY TO UBE FUNCTIONALITY IN MULTIPLE OPERATING ROOMS: the system can be quickly moved via the dedicated remote control and utilized in any operating room, thus maximizing its employment. NO LONGER MOVING THE PATIENT: the system follows the treatment, thus avoids the need of moving patients from the surgical table.

HARD-DOCKING PROCEDURE: fast and easy procedure that can be performed by expert teams in less than five minutes; safe and executable in any clinical configuration, thanks to the LIAC architecture and the wide range of accompanying applicators; a reliable system that provides an accurate and repeatable beam collimation on the target. Ed DEGREES OF FREEDOM: 3 independent degrees of freedom of the radiant head (elevation, roll angle and pitch), and 2 degrees of freedom of the mobile unit (shift on the plane) permit to easily reach any district. LIGHT WEIGHT OF MOBILE UNIT: the impact in the...

LIAC is able to treat any clinical volume in the lOeRT environment. By selecting the correct applicator/energy combination, it is possible to treat any neoplastic disease effectively and safely. The 1007o PMMA (polymethylmethacrylate) applicator allows: - implementation of the safest and fastest hard-docking technique; - direct visualization of the surgical breach, thanks to the transparency of the material and the length of the terminal applicator; - full compatibility with x-rays imaging; - increase of the surface dose by more than 907o, thus avoiding the need of any bolus. Depth in water...

The lOeRT technique ensures reduction of dose exposure of the healthy tissue during the irradiation. In breast cancer treatment, the use of a radioprotection disc (Italian Patent no. 1392099) temporarily inserted between the target and the chest wall fully protects the healthy tissue underneath. The disc is a medical device made of steel and PTFE (polytetrafluoroethylene), biocompatible and sterilizable materials; is available in the following diameters: 6,7,8, 9 10 and 11 cm. The disc has 4 holes placed along the crown which allow adhesion to underlying tissues, thus ensuring their...

REMARKS/IOERTeffects BREAST APPLICATION I0RT (applicator ^ 8cm), Charlson comorbidity index * 3 and chemotherapy improve OS Median survival: 23 m RO vs 10 m R2/unresectable 987o local control with lOeRT boost lOeRT significant improvement of local control Any stage lOeRT promoted local control Prognostic index for risk-adapted treatment. No toxicity increment by lOeRT lOeRT as SINGLE DOSE: the ELIOT Protocol [17] The 5-year rate of ipsilateral breast recurrence according to 2009 ASTRO APBI guidelines [18] for a selected patients group is 1.57o [22]. The Update of ASTRO guidelines, published...

ADVANTAGES OF THE IDpRT TECHNIQUE: - improvement of local control; - reduction (in the case of boost) and elimination (in case of single dose) of the external radiotherapy cycle; - time zero between surgery and radiation, resulting in inhibition of the repopulation of neoplastic cells; - precision, thanks to direct visualization of the target; - significant reduction dose to healthy tissues; - minimization of side effects; -feasibility of the treatment as the only solution when external radiation therapy is not possible. TREATMENT TIMES IOeRTBOOST+ Hypofractionated external RT cycle...

EXTERNAL RADIATION THERAPY CYCLE Hypofractionated external radiation therapy cycle Standard external radiation therapy cycle ADVANTAGE: FOR FOCI FT Y .□VANTAGES FOR HE RATI EEN decrease of social costs associated to the need for care and lack of patient productivity. substantial reductions in waiting lists for radiotherapy centers. reduction of the entire cycle to a single day! elimination of side effects caused by conventional therapy decrease in costs to undergo treatment.

LIAC COMMISSIONING The LIAC commissioning is performed in accordance with primary international protocols through the use of standard dosimetric instrumentation, as well as use of the LIAC Monte Carlo Simulation proprietary software. The use of the Monte Carlo software allows to dramatically reduce (3 working days) the dosimetric characterization of the accelerator already during its acceptance test performed at the main factory. The clinical dosimetry of the totality of combinations (4 energies x 8 diameters of the applicator x 4 bevel angles) is immediately available, thus allowing to...

PAST PLUG COMMISSIONING AND & PLAY INSTALLATION WORLD WIDE: DIF-HJSdON Italy Austria Belgium Chile Costa Rica Cuba Ecuador Georgia Germany Greece Iran Kazakhstan Kuwait Mexico Poland Russia Saudi Arabia Spain Switzerland Thailand Turkey USA-Florida USA - Illinois USA - Oklahoma USA - Pennsylvania Venezuela

Nominal Energies (model 12 MeV) Nominal Energies (model 10 MeV) Surface Dose Beam Current Field Dimensions VALUE 6,8,10,12 [MeV] 4,6,8,10 [MeV] £ 85 % model 10 MeV * 87 7o model 12 MeV *1.5 [mA] Flatness (maximum energy value) Symmetry (maximum energy value) Applicator length Source Surface Distance (SSD) Dose rate (applicator 010 cm) E-gun pulse duration Long term stability Short term stability Linearity Stray X-radiation (PDD Bremsstrahlung tail) MOBILE UNIT Length Width Height Weight CONTROL UNIT Length Width Height Weight ELECTRICAL SPECIFICATIONS Temperature Relative humidity Voltage...