ChimerMarker™ Chimerism Genotyping Analysis and Monitoring Software – Reduces Analysis Time…. up to 85%‡ ChimerMarker™ software, developed in collaboration with Dr. Donald Kristt*, and validated† by laboratories in the U.S. and Europe, combines accurate size and allele calls (genotyping) with automated chimerism calculations and long term monitoring. The program integrates speed and accuracy with a biologist-friendly interface. Initial analysis is typically three steps to completion: • GENOTYPING donor(s) and recipient • AUTOMATED DETECTION of INFORMATIVE LOCI and MIXTURE DECONVOLUTION • LINKED...

Comprehensive Reports – Single time point analysis reports contain a header with user/institution ID, patient information and analysis parameters, an authorization box for initials/date. Customize the report by selecting from a variety of options. Two popular options are pictured here. Reports may be printed directly, or saved as an image file for electronic records. Complete electropherograms of the post-transplant sample with the chimerism report on the second page The informative loci, or selected loci, of the post-transplant sample, and pre-transplant samples with the results for each locus...

Monitoring Engraftment with Longitudinal Graphing ChimerMarker software contains an integrated Longitudinal Report function. The software appends new sample files to an existing graph producing a time study monitoring % chimerism trend. Both the chimerism results and longitudinal graph are saved in a single project file for easy recordkeeping. Longitudinal reports are saved with the project and may be printed directly or saved as an image. Single Donor Post-Transplant Monitoring Graph This example is a five year single donor study indicating an initial stability, but with a downward trend; alerting...

Audit Trail and User Management User management provides control of user access rights and generates a user and audit trail for each project. Access rights for each user are determined by the administrator – providing assurance that unauthorized individuals do not accidentally alter a project or analysis parameters. User management also provides user ID and Organization name in the header of the final clinical research reports. Password Protected Login Login Record Records Data Audit Trail Analysis

Preferences, Multi-Lineage Analysis and Automated Panel Construction The selectable preferences include labeling peak ratios by height or area; with multi-lineage capabilities for chimerism analysis of T-cells, B-cells, and other cell type populations. These populations may indicate graft-versus-host disease (GVHD) or graft rejection. In addition, there are functions for comparison of samples at different time points to conduct longitudinal studies and produce a comprehensive graph. Case specific panels are automatically constructed, using Donor and Recipient allele calls. ChimerMarker recognizes...

Maternal Cell Contamination ChimerMarker provides accurate genotyping of maternal and fetal samples and uses rigorous mixture analysis algorithms to automatically detect and quantify MCC for cord blood banking or to screen samples prior to prenatal testing on chorionic villus and amniotic fluid samples. Sample grouping allows the user to analyze multiple cases in the same project. The MCC application is directly linked to the main analysis screen - removing the error-prone step of data transfer. Computer System Requirements: Windows® PC OS: Windows® XP, Vista, Windows® 7 Processor: Pentium® III,...

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