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Detection of Drug-Resistant Mutations in Mycobacterium tuberculosis (Nucleic Acid Mass Spectrometry) Tuberculosis, caused by Mycobacterium tuberculosis infection, is one of the significant communicable diseases that pose a serious threat to human health. Drug-resistant mutations in Mycobacterium tuberculosis can develop resistance against anti-tuberculosis drugs. Drug-resistant tuberculosis has always been a focal and challenging aspect in tuberculosis prevention and control efforts. It not only requires prolonged and costly treatment but also has a low cure rate, posing a severe threat to the health of society and the general population. Therefore, accurate detection of drug-resistant mutations against anti-tuberculosis drugs is crucial for the diagnosis and treatment of tuberculosis. The global number of people reported to have been enrolled on treatment for MDR/RR-TB,2015-2021a Adults aged ≥15 years or age not reported Children aged 0-14 years DETECTION CONTENT Tuberculosis drugs Drug-resistant genes Analysis projects DETECTION METHOD Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) is a novel technique used for the analysis of biological molecules. It involves the formation of a thin co-crystallized film by irradiating the sample with a laser in the presence of a matrix. The matrix absorbs energy from the laser and transfers it to the biological molecules, causing their ionization. The ionized molecules are then accelerated through a flight tube by an electric field, and their time of flight to the detector is used to accurately determine their molecular weight, allowing for pre
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PRODUCT INFORMATION Product Name Mycobacterium tuberculosis resistance mutation site detection kit nucleic acid mass spectrometry Pack Size Instruments Validated Sample Type MassARRAY®DNAMass Spectrometry Gene Analysis System paraffin embedded tissue DETECTION SIGNIFICANCE Accurate identification of common drug-resistant gene mutation sites in clinically prevalent Mycobacterium tuberculosis strains, covering six anti-tuberculosis drugs (Rifampin, Ethambutol, Fluoroquinolones, Isoniazid, Streptomycin, and Pyrazinamide), can assist in the clinical treatment of tuberculosis. FEATURES &...
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