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HER2 Gene Amplification Detection

HER2 Gene Amplification Detection
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HER2 Gene Amplification Detection

Product catalog summary
Introduction
HER2 (Human Epidermal Growth Factor Receptor 2) is a critical prognostic marker in breast cancer, associated with poor response to conventional therapies and aggressive tumor behavior. Accurate detection of HER2 gene amplification is essential for effective clinical treatment and prognosis evaluation.
Detection Method
The document describes the use of Digital PCR for detecting HER2 gene amplification. This method offers high accuracy, precision, and objectivity, eliminating manual interpretation challenges and providing results consistent with fluorescence in situ hybridization (FISH).
HER2 Overexpression and Treatment
HER2 overexpression leads to tumor development. Herceptin, a monoclonal antibody drug approved in 1998, targets HER2 oncogene amplification, improving patient prognosis.
Features & Advantages
  • High sensitivity: Detects mutations with DNA content as low as 0.1%.
  • Accurate quantification: Enables timely detection of disease progression.
  • No need for internal controls: Reduces false-negative results.
  • Simple and fast: Results available within one working day.
Detection Significance
The test is significant for detecting HER2 gene amplification in various cancers, aiding in the selection of targeted therapies like trastuzumab and pertuzumab.
Detection Process
  1. Nucleic Acid Extraction
  2. Microdrop Preparation
  3. Microdrop PCR
  4. Data Analysis
  5. Report Generation
Product Information
  • Product Name: HER2 Gene Amplification Detection
  • Technology: Digital PCR
  • Pack Size: 24 tests/kit, 48 tests/kit
  • Instruments Validated: BIO-RAD: QX200
  • Sample Type: Tumor tissue, Peripheral blood
Contact Information
Xiamen Spacegen Co., Ltd. and Suzhou SpaceSeq MedLab Co., Ltd. provide contact details for further inquiries.
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Catalog excerpts

HER2 Gene Amplification Detection-1

HER2 Gene Amplification Detection (Digital PCR Method) Human epidermal growth factor receptor 2 (HER2) is an important prognostic factor for breast cancer. Breast cancers with HER2 overexpression have poor response to conventional chemotherapy and endocrine therapy, exhibit aggressive tumor invasion, shorter disease-free survival, and overall poor prognosis. Accurate detection and assessment of HER2 gene copy number in breast cancer and gastric cancer are crucial for clinical treatment and prognosis evaluation. HER2 testing results not only determine the suitability of targeted therapy for HER2 but also guide the selection of endocrine therapy, chemotherapy regimens, and prognosis assessment. Digital PCR detection results show high concordance with fluorescence in situ hybridization (FISH) and have advantages such as good accuracy, high precision, simple operational procedures, and objective results. The digital PCR detection method eliminates the need for manual interpretation, greatly overcoming the challenges associated with tumor heterogeneity in assessment. THE RESULT OF HER2 OVEREXPRESSION HER2 gene amplification Leading to tumor development leading to HER2 overexpression HER2 GENE TARGETING DRUG HERCEPTIN Herceptin was approved for the first time in 1998. As a monoclonal antibody drug, it can specifically inhibit the growth of cancer cells with HER2 oncogene amplification and greatly improve the prognosis of patients.

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HER2 Gene Amplification Detection-2

PRODUCT INFORMATION Product Name Pack Size HER2 Gene Amplification Detection Instruments Validated Sample Type Tumor tissue Peripheral blood DETECTION SIGNIFICANCE 1. It is used to detect HER2 gene amplification in patients with breast cancer, gastric cancer, colorectal cancer, endometrial cancer, etc., providing scientific evidence for the rational selection of drugs such as trastuzumab and pertuzumab in clinical practice. 2. It is applicable to patients with specific types of breast cancer, gastric cancer, colorectal cancer, endometrial cancer, etc. FEATURES & ADVANTAGES High sensitivity: Can...

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