Human Lung Cancer RET Gene Fusion Detection Kit (Real-Time PCR assay) RET GENE FUSION IN LUNG CANCER The RET proto-oncogene is located at 10q11.2 and is 60 kb long, including 21 exons. After the RET gene is fused, dimerization can be completed without ligands, which will cause the RET tyrosine kinase region and downstream MAPK, PI3K/AKT and other signaling pathways continuously activated，leading to cellular proliferation, migration, and differentiation. Gain-of-function alterations in RET have been implicated in human malignancy. KIF5B is the most common RET fusion partner in NSCLC, and seven different KIF5B-RET variants have been identified [1] DETECTED GENES Reaction Tube Fusion Partners and Exons

PRODUCT INFORMATION Product Name Pack Size Instruments Validated Sample Type Human Lung Cancer RET Gene Fusions Detection Kit Tumor tissue, Pleural and Ascites DETECTION SIGNIFICANCE ﹡Inoperable stage III and IV NSCLC patients should be detected for RET gene fusion before systemic treatment, and treatment should be guided by molecular classification. ﹡Select patients for the targeted treatment of NSCLC based on the presence of RET positivity. FEATURES & ADVANTAGES Accuracy and Reliability: Use pre-load PCR tube to effectively avoid cross-contamination. High Sensitivity: Sensitivity can reach...