Human Radiotherapeutic SideEffect-Related Gene SNP Detection Kit
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Human Radiotherapeutic Side Effect-Related Gene SNP Detection Kit （Next Generation Sequencing） TUMOR AND RADIOTHERAPEUTIC Radiotherapy is an effective means of comprehensive treatment for tumors. While inhibiting or killing tumor cells, it produces radiotherapy-induced toxic side effects that can cause great pain to patients and even affect the smooth progress of treatment. The differences in radiotherapy toxicity between individuals are significant. Detecting the expression of genes related to radiotherapy toxicity in tumor patients can predict the risk of adverse reactions in patients. The variability of radiotherapy toxicity is related to single nucleotide polymorphisms (SNPs) in related genes. Evaluating the SNPs of patients' related genes can predict their sensitivity to radiotherapy, thus providing patients with effective and minimally toxic treatment options to minimize the adverse effects of radiotherapy on tumor patients and maximize the therapeutic effects to improve patient survival. GENOTYPE AND RADIOTHERAPY For example: In radiotherapy for breast cancer, individuals with different DNMT1 genotypes have different risks of developing fibrosis caused by radiotherapy. Compared to patients with AA/AG genotypes, patients with the GG genotype have a lower probability of developing radiation-induced skin fibrosis. Cancer Res Treat. 2017;49(2):464-472 Types of Tumor Treatment Prostate cancer Head and neck cancer Breast cancer Types of Radiation Toxicity The G genotype increases gastrointestinal and genitourinary toxicity Patients with the A genotype may have an increased risk of developing radiation dermatitis compared to patients with the GG genotype Patients with the G genotype have an increased likelihood of developing radiation-induced skin fibrosis compared to patients with the the AA genotype Patients with the CC genotype have a higher risk of radiation pneumonitis compared to patients with the GC/GG genotype Patients with the GC/GG genotype have a lower risk of radiation esophagitis compared to patients with the CC genotype Lung cancer There is no direct correlation with radiation pneumonitis and lung injur

DETECTED GENES Using high-throughput sequencing on peripheral blood samples from tumor patients, this method comprehensively tests 61 SNP loci in 41 radiation-induced toxicity-related genes including XRCC1、TNFa、 TXNRD2、ERCC2、TGFBl、VEGF、DNMT1、TP53、XRCC3、LIN28B、MTHFR、PON1、GSTP1、ATM、NOS2、 APEX1、MLH1、IL8、CD44、LIG4、IL1A、CYP2C8、IL4、NEIL1、NBN、APC、NFKBIA、DEAD、Tpa、RAD51、 NFE2L2、GSTA1、MGMT、TDG、GSK3β、FSHR、MY03B、TGFBR2、KDM3B、HSPBl and TXN. This method provides comprehensive information to aid clinicians in predicting the efficacy and toxicity of radiotherapy, and in developing rational and feasible...