Our expertise in the pharmaceutical industry Robotics | Experts in Man and Machine

STÄUBLI PHARMA PLAYGROUND Smart solutions for the pharmaceutical industry New manufacturing, the demand for personalized medicines, new treatment options and innovative approaches in prevention and diagnostics are among the key challenges facing the pharmaceutical industry. These seismic shifts offer opportunities not only for traditional pharmaceutical providers, but also for technology companies from outside the sector. Over and above fulfilment of the industry’s stringent certification requirements, factors such as process reliability and flexibility play decisive roles. Rudolf M. Weiss, Global...

Specific need, adapted solution. Working in collaboration with industry play- for the production of APIs and biotherapeu- tion of packaging materials and automated ers over the years, Stäubli has amassed tics; industry-scale filling and packaging of processes in laboratories and pharmacies. substantial know-how. This benefits our liquid, powder and solid medicines; load- Our wealth of experience and range of ro- customers in the planning of every new pro- ing/unloading systems for freeze dryers, bots make Stäubli an automation specialist ject, including systems and assembly lines autoclaves,...

DRUGS DEVELOPMENT AND MANUFACTURING API research and production The Active Pharmaceutical Ingredient in- adhere to strict safety and quality standards dustry (API) are manufactured from raw ma- set by the country where it will be used. Main applications terials through both chemical and physical So, APIs manufactured in China or India  Bulk powder handling for use in the United States must still be in- Depending on the complexity of the mole- cule required, synthesis of APIs might need multi-step complex chemistry utilizing a At each complex production stages, Stäubli  Preparation petri dish...

A clean robot for perfect integration into the process API manipulation is a highly delicate step. In a closed and sterile environment, this stage can’t be performed by a human. The high payload Stericlean robot is perfectly integrated to give a secure and flexible solution. A Stericlean RX160 robot is manipulating active substances bucket in API production cell. Image provided by courtesy of SKAN AG Bulk sterile manufacturing This custom solution performs the filling of sterile products with high reliability, no risk of contamination and without personal exposure. Sterilization, filling, capping,...

DRUG PRODUCTION Liquid and solid production Pharmaceutical manufacturing is a highly expectations, production must be easily management of different RTU containers in scalable, the robot’s flexibility being a key order to change production easily, should The production is made in an isolator, factor to enable this. Whether in a small where decontamination is mandatory and isolator with a single robot capable of monitored. Almost every process can handling several independent or linked be automated to gain in flexibility and operations, or in a complete production line sterility. To respond efficiently...

Aseptic production under strict surveillance Main applictions:  Filling  De-nesting  Re-nesting  Bag and TUB opening  Inspection  Weighing  Transferring  Lyophilization  Capping  Stopper handling  Solid gravimetric filling  Compacting Cytotoxic vial filling line in an isolator Filling line for hyaluronic acid gel A Swiss plant construction firm has set the the tub, which is transported by a conveyor industry benchmark with its filling line for system to further processing stations. hyaluronic acid gel. At the heart of the sys- The entire process takes place in a sterile tem is a Stäubli...

DRUG PRODUCTION Secondary packaging of liquid and solid drugs Once individually packed, the journey to With quality assurance having the most Main applications shipment starts. The requirements within stringent requirements, we foresee more the secondary packaging area is less res- and more demand on inspection units. On trictive than within an isolator, however the the secondary packaging area, collaborati-  Device and component assembly cleanability of equipment still has an essen- ve aspects of the robots can be considered tial role. Throughout the task, traceability is to ensure safety of...

Pharmaceutical industry

AUXILIARY PROCESSES Auxiliary processes A lot of these auxiliary processes are still Main applications done manually in a major part of pharma revision will push the demand of automation upgrades around filling lines, near isolator and RABs. This automation will reach its peak with integration of mobile solutions. dryers Loading/Unloading of autoclaves oading/Unloading of parts L washers Component feeding Inspection processes Autonomous mobile robot is checking the integrity of isolator gloves by changing clove testing devices in a ghost shift Freeze dryer loading at the end of filling line....

"What can be automated, will be automated" Rudolf M. Weiss Global Head of Pharma Robotics Pharmaceutical industry

Biotherapy Biotherapy, including Advanced Therapy be delivered back to the patient. The manu- Main applications Medicinal Products, is the process of drug facturing guideline is now regulated by the production based on human cells. Many biotech companies already use this trend required as the environment of such cham-  Cell & gene therapy for vaccine manufacturing. A robot is able bers are highly monitored to ensure product to manage the whole process, including human cell modification, combining active ingredients, and then finally conditioning to  Filling  Shaking  Cleaning "Robotics will...

Skin 4D bio-printing Poietis has specialized in the development and manufacturing of human tissues using 4D bioprinting. Combining laser-assisted, micro-valve and extrusion bioprinting, it enables true versatility of bioprinting (from cell to spheroids) and offers the possibility of using a large number of biomaterials and hydrogels. Inspired by the principles of the 4.0 Industry, this new platform integrates automation and robotics technologies, coupled with numerous online sensors – including cell microscopy – and Artificial Intelligence processing. 4D printing with TX2-40 ceiling robot. ©Poietis...