Small implantable physio-loggers Logging Life Science

Advantages at a glance Minimally invasive, simple to set up and implant Stress-free, accurate measurements Biocompatible and reusable Long battery life

High performance, small size Available parameters in each size Physio loggers Choose parameters: Heart rate Activity Temperature Heart rate Activity Temperature Heart rate Temperature Activity and Temperature loggers Choose parameters: Activity Temperature Activity Temperature Activity Temperature

— Placebo — Non-prlmed — HINI-prlmed28 30 32 34 36 38 Temperature data from ferrets for three groups. Temperature is displayed as meanadeviation from baseline in 30min intervals from the day of H2N2 infection until day 38 (n=5-6). Image inspired from [1]. With sampling interval of 10 min at room temp Outside ranges available upon request [1] van de Ven, K., de Heij, F., van Dijken, H. et al. Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets. Commun Biol 3, 564 (2020).

Measure heart rate and body temperature simultaneously. Apply to a variety of studies Including circadian rhythm, stress response and baseline metabolic studies. The heart rate measurements are derived from a leadless single channel ECG. The electrodes are part of the housing, making the loggers easy to implant and explant. The loggers can measure heart rates ranging from 5 bpm to 1022 bpm and can record extended ECG records for periods where slow heart rates are expected. Heart Rate and temperature data for laboratory rats (Sprague-Dawley) during a cardiovascular screening. * With sampling interval...

Temperature and Activity data from a Baboon during an infection study showing fever and lethargy. Activity levels are displayed as hourly average of AvgEA values. For 1Hz sampling requency over 1 min, sampling interval 1-20 min, activity and temperature recorded simultaneously If all parameters are recorded simultaneously Outside ranges available upon request

Measuring three parameters in one device makes it easy to identify correlation between heart rate, activity, and temperature. This makes the loggers ideal for studies including stress response, hibernation, and studies on animals’ response to extreme temperatures. lAMiWWWl Data recorded with DST milli-HRT-ACT in Cynomolgus Macaque during an vaccine efficacy trial. Data for temperature, heart rate and activity are shown as hourly averages (± SD). * For sampling interval of 2-20 minutes; ECG sampled at 600Hz, Activity 1Hz over 1 minute. ** Outside ranges available upon request *** If all parameters...

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