EMPOWERING OUTCOMES SURGICAL SKIN CLOSURES Designed to address the limitations of traditional suture and staple-based technologies E APP Remove RED liner of the Clozex Closure device to expose clear adhesive pads. adhesive pads l-2mm from each wound edge. SAFER. FASTER. BETTER. Remove WHITE liners to secure adhesive closure pads to skin. Remove BLUE liners to prepare pulling straps. Pull both pulling straps away from the wound edges to align and approximate the skin Lower straps to adhere them to the tops of the closure device pads. Twist off each removable strap at perforation Faster Skin Closure Average 50% faster skin closure proven in 8 clinical studies Quickly and uniformly pull wound edges together Greater Control and Flexibility Interlaced design allows precise 3-dimensional control Approximate tissue across, laterally along, and perpendicular to wound edges Easy to Learn and Apply Color coded and numbered liners for step-by-step application Choose from 10 sizes and combinations to close any length incision or laceration Excellent Cosmetic Results • Non-invasive coaptive film technology • Eliminates scar producing tension and unwanted "track marks" caused by sutures and staples Safer, Non-invasive Design • Eliminates costly and concerning needlestick accidents * Reduces risk of surgical site infections caused by skin piercing, suture wicking, and residual tracks Patient Friendly Technology • Non-threatening, needleless closure of lacerations in emergency setting • May reduce need for local injection of anesthetics in Emergency Department EMPOWERING OUTCOMES

Select the Clozex Closure size(s) to match the incision shape and length. Multiple closures can be combined in series to achieve the desired length and geometric shape. Dry the skin area prior to and during application of closure devices. EMPOWERING OUTCOMES APPLY CLOZEX CLOSURE APPROXIMATE SKIN EDGES FINAL CLOSURE (HEMIA) Proven Advantages Across Specialties ► Plastic Surgery Saves Valuable Operating Room Time Clinically proven to provide 50% faster skin closure, reducing OR costs and freeing up surgeon and staff time. alidated by 8 Clinical Studies In independent, published studies, Clozex...