TECHNICAL DATASHEET Simpleware AS Cardio Release Version T-2022.03 March 7, 2022 Heart Segmentation and Landmarking • Anatomy-specific automated segmentation tool for heart blood pool and muscle – Tricuspid Valve Centroid – Vena Cava Ostium Centroid (inferior, superior) • Automatic segmentation suitable for use on CT scans • Segmentation and landmarking available for 3D and 4D frames • Automatic ROI detection within larger extent scans – Aorta – Left Atrium – Left Coronary Artery – Left Ventricle – Myocardium – Pulmonary Artery – Right Atrium – Right Coronary Artery – Right Ventricle • Landmarks placed on identified anatomy: – Aortic Commissure (1, 2 and 3) – Aortic Coronary Cusp (left, right, and posterior) – Aortic Coronary Ostium (left, right) – Atrial Appendage (left, right) – Coronary Sinus Ostium Centroid – Left Ventricle Apex – Left Ventricle Base – Right Ventricle Apex Aortic Valve Analysis • Analysis tool streamlining the workflow for computing aortic valve characteristics of: – Aorta valve cusp plane – Ostia distance – Sinus Valsalva – Sinotubular junction – Ascending Aorta centerline – Annulus representation General User Interface • Interactive anatomy diagrams indicate the expected output, if anatomies are present and identifiable in the input data • Toggle the segmentation of each available anatomy • Toggle the generation of landmarks • Landmarks accessible via the Measurements tool • Reduce region of interest to a sub-volume of a larger extent scan, either automatically or manually Simpleware AS Cardio (Auto Segmenter for Cardiology) provides anatomyspecific, automated segmentation tools from heart CT data using Machine Learning (

Scripting • Run AS Cardio tools via the Simpleware scripting API in Python and C# • Run with Console ScanIP for GUI-less processing from the command line ©2022 Synopsys, Inc. All rights reserved. Synopsys is a trademark of Synopsys, Inc. in the United States and other countries. A list of Synopsys trademarks is available at http://www.synopsys.com/copyright.html . All other names mentioned herein are trademarks or registered trademarks of their respective owners. 03/03/22.Simpleware-TDS-ASCardio-Let